1 | ID1, ID3
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| Combined Id1 and Id3 Deletion Leads to Severe Erythropoietic Disturbances.
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| Zhao Q, Chang C, Gonzalez JP, Alzahrani K, Button JL, Fraidenraich D.
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| PLoS One 11(4):e0154480. doi: 10.1371/journal.pone.0154480. eCollection 2016.
2016
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2 | ID1, ID2, ID3, ID4, ZBTB18
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| RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1-4 genes in the developing cortex.
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| Hirai S, Miwa A, Ohtaka-Maruyama C, Kasai M, Okabe S, Hata Y, Okado H.
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| EMBO J 31(5):1190-202. doi: 10.1038/emboj.2011.486. Epub 2012 Jan 10.
2012
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3 | ID1, LARP6
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| Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing.
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| Sun R, Chen W, Zhao X, Li T, Song Q.
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| Cell Biochem Funct 29(8):636-40. doi: 10.1002/cbf.1799. Epub 2011 Aug 23.
2011
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4 | ID1, ID3, SMURF2
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| Smurf2-mediated ubiquitination and degradation of Id1 regulates p16 expression during senescence.
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| Kong Y, Cui H, Zhang H.
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| Aging Cell 10(6):1038-46. doi: 10.1111/j.1474-9726.2011.00746.x. Epub 2011 Oct 7.
2011
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5 | ID1, ID3
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| ID1 and ID3 represent conserved negative regulators of human embryonic and induced pluripotent stem cell hematopoiesis.
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| Hong SH, Lee JH, Lee JB, Ji J, Bhatia M.
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| J Cell Sci 124(Pt 9):1445-52. Epub 2011 Apr 12.
2011
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6 | ID1, PRKCA
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| Protein kinase Cα signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium.
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| Hao F, Pysz MA, Curry KJ, Haas KN, Seedhouse SJ, Black AR, Black JD.
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| J Biol Chem 286(20):18104-17. doi: 10.1074/jbc.M110.208488. Epub 2011 Mar 18.
2011
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7 | ID1, RNF2
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| Id1 enhances RING1b E3 ubiquitin ligase activity through the Mel-18/Bmi-1 polycomb group complex.
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| Qian T, Lee JY, Park JH, Kim HJ, Kong G.
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| Oncogene 29(43):5818-27. Epub 2010 Aug 9.
2010
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8 | ID1, NR1D1
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| Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction.
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| Phelan CA, Gampe RT Jr, Lambert MH, Parks DJ, Montana V, Bynum J, Broderick TM, Hu X, Williams SP, Nolte RT, Lazar MA.
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| Nat Struct Mol Biol 17(7):808-14. Epub 2010 Jun 27.
2010
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9 | ID1, ID3
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| Targeting Id1 and Id3 by a specific peptide aptamer induces E-box promoter activity, cell cycle arrest, and apoptosis in breast cancer cells.
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| Mern DS, Hoppe-Seyler K, Hoppe-Seyler F, Hasskarl J, Burwinkel B.
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| Breast Cancer Res Treat 124(3):623-33. Epub 2010 Feb 27.
2010
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10 | ID1
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| Inhibitor of DNA binding-1 overexpression in prostate cancer: relevance to tumor differentiation.
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| Yu X, Xu X, Han B, Zhou R.
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| Pathol Oncol Res 15(1):91-6. Epub 2008 Aug 28.
2009
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11 | ID1
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| Id-1 expression in androgen-dependent prostate cancer is negatively regulated by androgen through androgen receptor.
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| Xu B, Sun Y, Tang G, Xu C, Wang L, Zhang Y, Ji J.
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| Cancer Lett 278(2):220-9. Epub 2009 Feb 7.
2009
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12 | ID1
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| Bone marrow and peripheral blood expression of ID1 in human gastric carcinoma patients is a bona fide indicator of lymph node and peritoneal metastasis.
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| Iwatsuki M, Fukagawa T, Mimori K, Nakanishi H, Ito S, Ishii H, Yokobori T, Sasako M, Baba H, Mori M.
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| Br J Cancer 100(12):1937-42. Epub 2009 Jun 2.
2009
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13 | ID1
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| Smad3 mediates immediate early induction of Id1 by TGF-beta.
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| Liang YY, Brunicardi FC, Lin X.
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| Cell Res 19(1):140-8.
2009
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14 | DTX1, ID1
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| Id1 attenuates Notch signaling and impairs T-cell commitment by elevating Deltex1 expression.
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| Wang HC, Perry SS, Sun XH.
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| Mol Cell Biol 29(17):4640-52. Epub 2009 Jun 29. 2009
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15 | ID1
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| ID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling.
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| Wood AD, Chen E, Donaldson IJ, Hattangadi S, Burke KA, Dawson MA, Miranda-Saavedra D, Lodish HF, Green AR, Göttgens B.
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| Blood 114(9):1820-30. Epub 2009 Jul 1.
2009
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16 | ID1
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| Identification of a novel estrogen receptor beta1 binding partner, inhibitor of differentiation-1, and role of ERbeta1 in human breast cancer cells.
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| Chen L, Qiu J, Yang C, Yang X, Chen X, Jiang J, Luo X.
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| Cancer Lett 278(2):210-9. Epub 2009 Feb 13.
2009
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17 | ID1, ID2, ITF2
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| Expression of Id and ITF-2 genes in the mammary gland during pregnancy.
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| Itahana Y, Piens M, Fong S, Singh J, Sumida T, Desprez PY.
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| Biochem Biophys Res Commun 372(4):826-30. Epub 2008 Jun 2.
2008
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18 | ARID3A, ID1
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| Cross talk between Id1 and its interactive protein Dril1 mediate fibroblast responses to transforming growth factor-beta in pulmonary fibrosis.
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| Lin L, Zhou Z, Zheng L, Alber S, Watkins S, Ray P, Kaminski N, Zhang Y, Morse D.
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| Am J Pathol 173(2):337-46. Epub 2008 Jun 26.
2008
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19 | ID1
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| ID genes mediate tumor reinitiation during breast cancer lung metastasis.
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| Gupta GP, Perk J, Acharyya S, de Candia P, Mittal V, Todorova-Manova K, Gerald WL, Brogi E, Benezra R, MassaguŽ J.
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| Proc Natl Acad Sci U S A 104(49):19506-11. Epub 2007 Nov 28. 2007
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20 | ZBTB16, TP53INP1, TERT, ID3, ID1
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| Identification of apoptosis-related PLZF target genes.
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| Bernardo MV, Yelo E, Gimeno L, Campillo JA, Parrado A.
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| Biochem Biophys Res Commun 359(2):317-22. Epub 2007 May 24. 2007
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21 | CEBPA, ID1
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| Absence of the transcription factor CCAAT enhancer binding protein {alpha} results in loss of myeloid identity in bcr/abl-induced malignancy.
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| Wagner K, Zhang P, Rosenbauer F, Drescher B, Kobayashi S, Radomska HS, Kutok JL, Gilliland DG, Krauter J, Tenen DG.
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| Proc Natl Acad Sci U S A 103(16):6338-43. Epub 2006 Apr 10. 2006
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22 | MECP2, ID1, ID2, ID3, ID4
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| Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome.
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| Peddada S, Yasui DH, LaSalle JM.
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| Hum Mol Genet 15(12):2003-14. Epub 2006 May 8. 2006
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23 | ID1, ID3
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| Id proteins negatively regulate basic helix-loop-helix transcription factor function by disrupting subnuclear compartmentalization.
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| O'Toole PJ, Inoue T, Emerson L, Morrison IE, Mackie AR, Cherry RJ, Norton JD.
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| J Biol Chem 278(46):45770-6. Epub 2003 Sep 1.
2003
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24 | ID1
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| Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter.
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| Korchynskyi O, ten Dijke P.
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| J Biol Chem 277(7):4883-91. 2002
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25 | ID1
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| Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex.
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| Singh J, Murata K, Itahana Y, Desprez PY.
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| Oncogene 21(12):1812-22. 2002
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26 | ID1
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| Id-1 stimulates serum independent prostate cancer cell proliferation through inactivation of p16(INK4a)/pRB pathway.
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| Ouyang XS, Wang X, Ling MT, Wong HL, Tsao SW, Wong YC.
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| Carcinogenesis 23(5):721-5. 2002
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27 | ID1
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| Down-regulation of Id-1 expression is associated with TGF beta 1-induced growth arrest in prostate epithelial cells.
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| Ling MT, Wang X, Tsao SW, Wong YC.
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| Biochim Biophys Acta 1570(3):145-52. 2002
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28 | CDKN2A, ID1
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| The transcriptional repressor of p16/Ink4a, Id1, is up-regulated in early melanomas.
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| Polsky D, Young AZ, Busam KJ, Alani RM.
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| Cancer Res 61(16):6008-11. 2001
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29 | ID1, ARFGAP2
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| Molecular cloning and characterization of a zinc finger protein involved in Id-1-stimulated mammary epithelial cell growth.
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| Singh J, Itahana Y, Parrinello S, Murata K, Desprez PY.
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| J Biol Chem 276(15):11852-8. 2001
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30 | CDKN2A, ETS1, ETS2, ID1
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| Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence.
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| Ohtani N, Zebedee Z, Huot TJ, Stinson JA, Sugimoto M, Ohashi Y, Sharrocks AD, Peters G, Hara E.
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| Nature 409(6823):1067-70. 2001
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31 | ID1, ID3
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| Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts.
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| Lyden D, et al.
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| Nature 401(6754):670-7 1999
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32 | ID1
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| Genomic organization, sequence, and chromosomal localization of the human helix-loop-helix Id1 gene.
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| Nehlin JO, et al.
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| Biochem Biophys Res Commun 231 : 628-634. 1997
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33 | ID1, ID2
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| Chromosomal assignment of human ID1 and ID2 genes.
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| Mathew S, et al.
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| Genomics 30 : 385-387. 1995
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34 | ID1
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| Id gene expression during development and molecular cloning of the human Id-1 gene.
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| Zhu W, Dahmen J, Bulfone A, Rigolet M, Hernandez MC, Kuo WL, Puelles L, Rubenstein JL, Israel MA.
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| Brain Res Mol Brain Res 30(2):312-26. 1995
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35 | ID1, ID2, ID3, ID4
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| The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3.
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| R•echmann V, et al.
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| Nucleic Acids Res 22 : 749-755. 1994
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36 | ID1
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| Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts.
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| Hara E, Yamaguchi T, Nojima H, Ide T, Campisi J, Okayama H, Oda K.
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| J Biol Chem 269(3):2139-45. 1994
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37 | ID1, ID2
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| Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins.
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| Sun XH, et al.
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| Mol Cell Biol 11 : 5603-5611. 1991
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