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FLASH GENE
Symbol HRH3 contributors: mct/npt - updated : 25-06-2008
HGNC name histamine receptor H3
HGNC id 5184
Location 20q13.33      Physical location : 60.790.016 - 60.795.323
Synonym name G protein-coupled receptor 97
Synonym symbol(s) GPCR97, HH3R, H3R
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
CDH4 20q13.3 cadherin 4, type 1, R-cadherin (retinal) FLJ22202 20q13.33 hypothetical protein FLJ22202 TAF4 20q13.3 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa C20orf40 20q13.33 chromosome 20 open reading frame 40 PSMA7 20q133 proteasome (prosome, macropain) subunit, alpha type, 7 SS18L1 20q13.2-q13.3 synovial sarcoma translocation gene on chromosome 18-like 1 GTPBP5 20 GTP binding protein 5 (putative) HRH3 20q13.3 histamine receptor H3 OSBPL2 20q13.3 oxysterol binding protein-like 2 ADRM1 20q13.33 adhesion regulating molecule 1 LAMA5 20q13.2-q13.3 laminin, alpha 5 RPS21 20q13.3 ribosomal protein S21 C20orf150 20q13.33 chromosome 20 open reading frame 150 C20orf151 20q13.33 chromosome 20 open reading frame 151 GATA5 20q11.21-q11.22 GATA binding protein 5 RPL7P3 20q13.33 ribosomal protein L7 pseudogene 3 C20orf166 20q13.33 chromosome 20 open reading frame 166 FLJ30313 20q13.33 hypothetical protein FLJ30313 LOC388805 20 LOC388805 FLJ32154 20q13.33 hypothetical protein FLJ32154 SLCO4A1 20q13.33 solute carrier organic anion transporter family, member 4A1 NTSR1 20q13 neurotensin receptor 1 (high affinity) LOC391261 20 similar to putative glycine-rich protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2699 48.7 445 - Dastmalchi (2008)
- splicing - - 415 - Coge
- splicing - - 365 - Coge
- splicing - - 329 - Coge
- splicing - - 431 - Coge
- splicing - - 326 - Coge
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   specific
 braindiencephalonthalamus highly
 brainbasal nucleicaudate nucleus highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane domains (7TM)
  • HOMOLOGY
    Homologene
    FAMILY
  • G protein-coupled receptors family 1
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • regulating the neurotransmitter release
  • increasing voltage dependent calcium current in smooth muscles (and innervation of blood vessels)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interazcting wth CLIC4 (binding to the C-terminus of HRH3, CLIC4 plays a critical role in regulation of the receptor cell surface expression)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS