Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

HRH3

contributors: mct/npt - updated : 25-06-2008

HGNC name	histamine receptor H3
HGNC id	5184

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20q13.33      Physical location : 60.790.016 - 60.795.323
Synonym name	G protein-coupled receptor 97
Synonym symbol(s)	GPCR97, HH3R, H3R

DNA

TYPE	functioning gene
STRUCTURE	5.00 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed HRH3 - - 2699 48.7 445 - Dastmalchi (2008) HRH3 Delta Isof1 - splicing - - 415 - Coge HRH3 Delta Isof2 - splicing - - 365 - Coge HRH3 Delta Isof3 - splicing - - 329 - Coge HRH3 Delta TM2 - splicing - - 431 - Coge HRH3 Delta TM5 - splicing - - 326 - Coge

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       specific   brain diencephalon thalamus   highly   brain basal nuclei caudate nucleus   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane domains (7TM)

HOMOLOGY

Homologene

FAMILY

G protein-coupled receptors family 1

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	regulating the neurotransmitter release
	increasing voltage dependent calcium current in smooth muscles (and innervation of blood vessels)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interazcting wth CLIC4 (binding to the C-terminus of HRH3, CLIC4 plays a critical role in regulation of the receptor cell surface expression)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS