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FLASH GENE
Symbol HRH3 contributors: mct/npt - updated : 25-06-2008
HGNC name histamine receptor H3
HGNC id 5184
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2699 48.7 445 - Dastmalchi (2008)
- splicing - - 415 - Coge
- splicing - - 365 - Coge
- splicing - - 329 - Coge
- splicing - - 431 - Coge
- splicing - - 326 - Coge
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   specific
 braindiencephalonthalamus highly
 brainbasal nucleicaudate nucleus highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane domains (7TM)
  • HOMOLOGY
    Homologene
    FAMILY
  • G protein-coupled receptors family 1
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • regulating the neurotransmitter release
  • increasing voltage dependent calcium current in smooth muscles (and innervation of blood vessels)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interazcting wth CLIC4 (binding to the C-terminus of HRH3, CLIC4 plays a critical role in regulation of the receptor cell surface expression)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS