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FLASH GENE
Symbol HNRNPK contributors: mct - updated : 04-10-2014
HGNC name heterogeneous nuclear ribonucleoprotein K
HGNC id 5044
Location 9q21.32      Physical location : 86.582.998 - 86.595.569
Synonym name
  • core protein K, acidic
  • transformation upregulated nuclear protein
  • Synonym symbol(s) HNRPK, RNPKP, CSBP, TUNP
    DNA
    TYPE functioning gene
    STRUCTURE 12.57 kb     17 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text
  • four alternatively spliced isoforms A, B, C, D (Dejgaard)
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 2936 50 463 - 2005 16360036
  • having a distinct 5' UTR, compared to variant 1
  • encoding the same protein than variant 1
  • 17 - 2960 51 464 - 2005 16360036
  • lacking 60 bases compared to variant 1
  • causing a frame shift near the end of the coding region
  • 17 - 2995 51 464 - 2005 16360036
    encoding the same protein than variant 3
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreastmammary gland highly
     female systemuterus  moderately
    Respiratoryrespiratory tractlarynx  predominantly
    Skin/Tegumentskin   moderately
    Urinarybladder   highly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • two RGG boxes
  • three K homology (KH) motifs, HNRNP K-homology (KH) domains, and tyrosine 458 in KH domain 3 of HNRNPK is important for the differentiation control element (DICE) interaction
  • conjugated RiboP
    mono polymer complex
    HOMOLOGY
    interspecies ortholog to rattus Hnrpk
    ortholog to murine Hnrpk
    Homologene
    FAMILY HNRP family
  • subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs)
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • playing a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences
  • may have a role during cell cycle progession
  • involved in the regulation of transcription, translation, nuclear transport, and signal transduction
  • serving as a cofactor for TP53
  • nuclear target of TCR-activated ERK and required for T-cell late activation
  • mediates antiapoptotic activity in part by inducing downstream antiapoptotic genes
  • exert various functional roles in the nucleus, cytoplasm, and mitochondria to affect different cellular processes including chromatin remodeling, transcription, splicing, and translation
  • playing key roles in coordinating transcriptional responses to DNA damage
  • involved in the translational control and stabilization of mRNAs in erythroid cells
  • promotes tumor cell survival in the absence of cell-cell contact, and is indispensable for tumor cell viability
  • CELLULAR PROCESS nucleotide, transcription, regulation
    protein, translation regulation
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism nucleic
    signaling signal transduction
    a component component of heterogeneous nuclear ribonucleoprotein complex
    INTERACTION
    DNA binding to poly(C) single-stranded DNA
    RNA binding
    small molecule
    protein
  • HCV core protein
  • first protein identified that directly interacts with and regulates the AR translational apparatus
  • arginine-methylated by direct interaction with PRMT1
  • CFLAR expression is transcriptionally regulated by HNRNPK and nucleolin
  • important transactivator for LDLR gene transcription
  • associated with the EGR1 but not c-MYC mRNAs
  • during oligodendrocyte differentiation and myelination ITGA6 beta1 interacts with HNRNPK, an mRNA-binding protein, which binds to MBP mRNA and translocates from the nucleus to the myelin sheath
  • cell & other
    REGULATION
    induced by DNA damage
    Phosphorylated by AURKA (Aurora-A phosphorylates HNRNPK, a transcriptional coactivator of TP53, on serine 379)
    Other is regulated by PRMT family proteins (Chan 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    targeting of HNRNPK by granzymes contributes to or reinforces the cell death mechanisms by which cytotoxic lymphocytes eliminate tumor cells
    diabete  
    may be potential targets in the treatment of hypertension and kidney injury in diabetes
    ANIMAL & CELL MODELS
  • insulin prevents hypertension and attenuates kidney injury, at least in part, through suppressing renal Agt transcription via upregulation of hnRNP F and hnRNP K expression in diabetic Akita mice