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FLASH GENE
Symbol HNRNPK contributors: mct - updated : 04-10-2014
HGNC name heterogeneous nuclear ribonucleoprotein K
HGNC id 5044
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • two RGG boxes
  • three K homology (KH) motifs, HNRNP K-homology (KH) domains, and tyrosine 458 in KH domain 3 of HNRNPK is important for the differentiation control element (DICE) interaction
  • conjugated RiboP
    mono polymer complex
    HOMOLOGY
    interspecies ortholog to rattus Hnrpk
    ortholog to murine Hnrpk
    Homologene
    FAMILY HNRP family
  • subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs)
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • playing a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences
  • may have a role during cell cycle progession
  • involved in the regulation of transcription, translation, nuclear transport, and signal transduction
  • serving as a cofactor for TP53
  • nuclear target of TCR-activated ERK and required for T-cell late activation
  • mediates antiapoptotic activity in part by inducing downstream antiapoptotic genes
  • exert various functional roles in the nucleus, cytoplasm, and mitochondria to affect different cellular processes including chromatin remodeling, transcription, splicing, and translation
  • playing key roles in coordinating transcriptional responses to DNA damage
  • involved in the translational control and stabilization of mRNAs in erythroid cells
  • promotes tumor cell survival in the absence of cell-cell contact, and is indispensable for tumor cell viability
  • CELLULAR PROCESS nucleotide, transcription, regulation
    protein, translation regulation
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism nucleic
    signaling signal transduction
    a component component of heterogeneous nuclear ribonucleoprotein complex
    INTERACTION
    DNA binding to poly(C) single-stranded DNA
    RNA binding
    small molecule
    protein
  • HCV core protein
  • first protein identified that directly interacts with and regulates the AR translational apparatus
  • arginine-methylated by direct interaction with PRMT1
  • CFLAR expression is transcriptionally regulated by HNRNPK and nucleolin
  • important transactivator for LDLR gene transcription
  • associated with the EGR1 but not c-MYC mRNAs
  • during oligodendrocyte differentiation and myelination ITGA6 beta1 interacts with HNRNPK, an mRNA-binding protein, which binds to MBP mRNA and translocates from the nucleus to the myelin sheath
  • cell & other
    REGULATION
    induced by DNA damage
    Phosphorylated by AURKA (Aurora-A phosphorylates HNRNPK, a transcriptional coactivator of TP53, on serine 379)
    Other is regulated by PRMT family proteins (Chan 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    targeting of HNRNPK by granzymes contributes to or reinforces the cell death mechanisms by which cytotoxic lymphocytes eliminate tumor cells
    diabete  
    may be potential targets in the treatment of hypertension and kidney injury in diabetes
    ANIMAL & CELL MODELS
  • insulin prevents hypertension and attenuates kidney injury, at least in part, through suppressing renal Agt transcription via upregulation of hnRNP F and hnRNP K expression in diabetic Akita mice