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FLASH GENE

Symbol

HNRNPK

contributors: mct - updated : 04-10-2017

HGNC name	heterogeneous nuclear ribonucleoprotein K
HGNC id	5044

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	12.57 kb     17 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	four alternatively spliced isoforms A, B, C, D (Dejgaard)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_031262 17 - 2936 NP_112552 50 463 - 2005 16360036 having a distinct 5' UTR, compared to variant 1 encoding the same protein than variant 1 NM_031263 17 - 2960 NP_112553 51 464 - 2005 16360036 lacking 60 bases compared to variant 1 causing a frame shift near the end of the coding region NM_002140 17 - 2995 NP_002131 51 464 - 2005 16360036 encoding the same protein than variant 3

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system breast mammary gland   highly   female system uterus     moderately Respiratory respiratory tract larynx     predominantly Skin/Tegument skin       moderately Urinary bladder       highly Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Epithelial barrier/lining

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES		acid
STRUCTURE

motifs/domains	two RGG boxes
	three K homology (KH) motifs, HNRNP K-homology (KH) domains, and tyrosine 458 in KH domain 3 of HNRNPK is important for the differentiation control element (DICE) interaction

conjugated

RiboP

mono polymer

complex

HOMOLOGY

interspecies	ortholog to rattus Hnrpk
	ortholog to murine Hnrpk

Homologene

FAMILY	HNRP family
	subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs)

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm

basic FUNCTION	playing a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences
	may have a role during cell cycle progession
	involved in the regulation of transcription, translation, nuclear transport, and signal transduction
	serving as a cofactor for TP53
	nuclear target of TCR-activated ERK and required for T-cell late activation
	mediates antiapoptotic activity in part by inducing downstream antiapoptotic genes
	exert various functional roles in the nucleus, cytoplasm, and mitochondria to affect different cellular processes including chromatin remodeling, transcription, splicing, and translation
	playing key roles in coordinating transcriptional responses to DNA damage
	involved in the translational control and stabilization of mRNAs in erythroid cells
	promotes tumor cell survival in the absence of cell-cell contact, and is indispensable for tumor cell viability

CELLULAR PROCESS	nucleotide, transcription, regulation
	protein, translation regulation

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

nucleic

signaling

signal transduction

a component

component of heterogeneous nuclear ribonucleoprotein complex

INTERACTION

DNA	binding to poly(C) single-stranded DNA

RNA

binding

small molecule

protein	HCV core protein
	first protein identified that directly interacts with and regulates the AR translational apparatus
	arginine-methylated by direct interaction with PRMT1
	CFLAR expression is transcriptionally regulated by HNRNPK and nucleolin
	important transactivator for LDLR gene transcription
	associated with the EGR1 but not c-MYC mRNAs
	during oligodendrocyte differentiation and myelination ITGA6 beta1 interacts with HNRNPK, an mRNA-binding protein, which binds to MBP mRNA and translocates from the nucleus to the myelin sheath
	methylated HNRNPK acts on RPS19 to regulate ALOX15 synthesis in erythropoiesis

cell & other

REGULATION

induced by

DNA damage

Phosphorylated by

AURKA (Aurora-A phosphorylates HNRNPK, a transcriptional coactivator of TP53, on serine 379)

Other

is regulated by PRMT family proteins (Chan 2009)

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     targeting of HNRNPK by granzymes contributes to or reinforces the cell death mechanisms by which cytotoxic lymphocytes eliminate tumor cells diabete     may be potential targets in the treatment of hypertension and kidney injury in diabetes

ANIMAL & CELL MODELS

insulin prevents hypertension and attenuates kidney injury, at least in part, through suppressing renal Agt transcription via upregulation of hnRNP F and hnRNP K expression in diabetic Akita mice