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FLASH GENE

Symbol

HEBP2

contributors: mct - updated : 27-08-2012

HGNC name	heme binding protein 2
HGNC id	15716

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q23.3      Physical location : 138.725.335 - 138.734.582
Synonym name	chromosome 6 open reading frame 34
	placental protein 23
	protein SOUL
Synonym symbol(s)	SOUL, C6orf34, KIAA1244, PP23, RP3-422G23.1

DNA

TYPE	functioning gene
STRUCTURE	9.25 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014320 4 - 1282 NP_055135 22.9 205 - 1999 10640688

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon epithalamus pineal gland highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, perinatal

Text	placenta at term (

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a sequence homologous with the BH3 (Bcl-2 homology 3) domains

HOMOLOGY

interspecies	homolog to murine Hebp
	homolog to E.coli Rob transcription factor

Homologene

FAMILY	heme binding protein (HEBP) family
	BH3-only protein family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
text	perinuclear localization

basic FUNCTION	besides its heme-binding properties, promotes necrotic cell death by inducing mitochondrial permeability transition
	can be a novel member of the BH3 domain-only proteins that cannot induce cell death alone but can facilitate both outer and inner mitochondrial membrane permeabilization and predominantly necrotic cell death in oxidative stress
	induce apoptosis by provoking the mitochondrial permeability transition

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

porphyrin/heme

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacts with the anti-apoptotic protein BCL2L1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS