Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HEBP2 contributors: mct - updated : 27-08-2012
HGNC name heme binding protein 2
HGNC id 15716
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonepithalamuspineal glandhighly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, perinatal
Text placenta at term (
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a sequence homologous with the BH3 (Bcl-2 homology 3) domains
  • HOMOLOGY
    interspecies homolog to murine Hebp
    homolog to E.coli Rob transcription factor
    Homologene
    FAMILY
  • heme binding protein (HEBP) family
  • BH3-only protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text perinuclear localization
    basic FUNCTION
  • besides its heme-binding properties, promotes necrotic cell death by inducing mitochondrial permeability transition
  • can be a novel member of the BH3 domain-only proteins that cannot induce cell death alone but can facilitate both outer and inner mitochondrial membrane permeabilization and predominantly necrotic cell death in oxidative stress
  • induce apoptosis by provoking the mitochondrial permeability transition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism porphyrin/heme
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the anti-apoptotic protein BCL2L1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS