Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HEBP2 contributors: mct - updated : 27-08-2012
HGNC name heme binding protein 2
HGNC id 15716
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a sequence homologous with the BH3 (Bcl-2 homology 3) domains
    • HOMOLOGY
    interspecies homolog to murine Hebp
    homolog to E.coli Rob transcription factor
    Homologene
    FAMILY
  • heme binding protein (HEBP) family
  • BH3-only protein family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text perinuclear localization
    basic FUNCTION
  • besides its heme-binding properties, promotes necrotic cell death by inducing mitochondrial permeability transition
  • can be a novel member of the BH3 domain-only proteins that cannot induce cell death alone but can facilitate both outer and inner mitochondrial membrane permeabilization and predominantly necrotic cell death in oxidative stress
  • induce apoptosis by provoking the mitochondrial permeability transition
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism porphyrin/heme
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the anti-apoptotic protein BCL2L1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS