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Symbol GRIA1 contributors: mct/npt/pgu - updated : 23-08-2015
HGNC name glutamate receptor, ionotropic, AMPA 1
HGNC id 4571
Location 5q33.2      Physical location : 152.870.083 - 153.193.428
Synonym name
  • AMPA-selective glutamate receptor 1
  • AMPA 1
  • Synonym symbol(s) GLUR1, GLUH1, GLURA, HBGR1, GluR-K1, MGC133252, AMPAR, GLUA1
    TYPE functioning gene
    STRUCTURE 323.35 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - SPARC /D5S1699 - GLRA1 - D5S2077 - D5S2909 - D5S2910 - D5S119 - D5S673 - D5S1532 - D5S2910 - D5S209 - D5S410 /D5S670 - GRIA1 - D5S1431 - D5S2012 - D5S497 - D5S1698 - D5S2911 - D5S662 - D5S1507 - D5S487 - qter
    Physical map
    SLC36A2 5q33.1 solute carrier family 36 (proton/amino acid symporter), member 2 LOC391840 5 similar to Thyroid hormone receptor-associated protein complex 240 kDa component (Trap240) (Activator-recruited cofactor 250 kDa component) (ARC250) LOC391841 5 similar to hypothetical protein DKFZp761H0421 SLC36A1 5q33.1 solute carrier family 36 (proton/amino acid symporter), member 1 FAT2 5q31-q32 FAT tumor suppressor homolog 2 (Drosophila) SPARC 5q32 secreted protein, acidic, cysteine-rich (osteonectin) ATOX1 5q32-q33 ATX1 antioxidant protein 1 homolog (yeast) LOC389338 5 LOC389338 G3BP 5q33.3 LOC389338 GLRA1 5q32 glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome) GLULL1 5q33 glutamate-ammonia ligase (glutamine synthase)-like 1 NMU2R 5q33.2 neuromedin U receptor 2 GRIA1 5q33 glutamate receptor, ionotropic, AMPA 1 C5orf3 5q31-q32 chromosome 5 open reading frame 3 MFAP3 5q32 microfibrillar-associated protein 3 GALNT10 5q33.2 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) FLJ11526 5q33.2 hypothetical protein FLJ11526 HAND1 5q32 heart and neural crest derivatives expressed 1 LOC389339 5 LOC389339 LARP 5q33.2 likely ortholog of mouse la related protein C5orf4 5q31-q32 chromosome 5 open reading frame 4 CNOT8 5q31-q33 CCR4-NOT transcription complex, subunit 8 GEMIN5 5q33.3 gem (nuclear organelle) associated protein 5 MRPL22 5q33.1-q33.3 mitochondrial ribosomal protein L22 LOC285643 5q33.2 similar to Chromosome-associated kinesin KIF4A (Chromokinesin) LOC391842 5 similar to 60S ribosomal protein L6 (TAX-responsive enhancer element binding protein 107) (TAXREB107) (Neoplasm-related protein C140)
    TRANSCRIPTS type messenger
    text with flip and flop isoforms
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 5747 101.4 906 - 1995 7877986
    16 - 5747 101.4 906 - 1995 7877986
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebraincerebral cortex  
     spinal cordanterior horn  highly Homo sapiens
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage glioblastoma cell lineage
    cell lines
    at STAGE
  • ligand binding site in the N terminal region
  • four transmembrane segments (4TM), one of which forming the wall of the channel, and a large intracellular loop
  • C-terminal domain of GRIA1 controls AMPA receptor function and trafficking during synaptic plasticity in the central nervous system
  • conjugated ubiquitinated
    interspecies homolog to murine Gria1
  • glutamate-gated ion channel family
  • CATEGORY protooncogene , signaling , receptor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • ligand gated ion (Cl) channel
  • glutamate receptor, subunit 1, ionotropic, AMPA (amino-3-hydroxy5 methyl-isoxazole-propionic) class
  • promotes dendrite growth in a non-cell-autonomous manner
  • mediating the fast component of excitatory post synaptic currents in the central nervous system
  • play an important role in synaptic plasticity and contribute to cell death under excitotoxic conditions
  • with GRIA2, GRIA3, GRIN2B, mediate fast synaptic transmission in the brain
  • spatial working memory (SWM) requires GRIA1 action in cortical circuits but is only partially dependent on GRIA1-containing AMPA receptors in hippocampus
  • important roles for FXR2 and GRIA1 in neuronal development, and functional convergence between fragile X proteins in this neuronal development
    a component
    small molecule
  • interacting with and signaling through the protein-kinase LYN
  • EPB41L1 is required for activity-dependent GRIA1 insertion, and disrupting EPB41L1-dependent GRIA1 insertion decreased surface expression of GRIA1 and the expression of long-term potentiation
  • direct interaction between GRIA1, AND FRRS1L
  • NMDA receptor activation regulates synaptic plasticity by causing endocytosis of AMPA receptor GRIA1
  • CREB1 is necessary for the specific maintenance of the GRIA1 subunit and for its trafficking within the post-synaptic densities (PSD) during the occurrence of learning
  • FMR1 and FXR2 additively promote the maturation of new neurons by regulating a common target, the AMPA receptor GRIA1, but via distinct mechanisms
  • CPT1C binds GRIA1 and GRIA2 and that the three proteins have the same expression profile during neuronal maturation
  • cell & other
    Other E3 ubiquitin ligase NEDD4 responsible for GRIA1 ubiquitination, a modification that regulates multiple aspects of GRIA1 molecular biology including trafficking, localization and stability
    S-nitrosylation of GRIA1 enhances S831 phosphorylation, facilitates the associated AMPA receptor conductance increase, and results in endocytosis by increasing receptor binding to the AP2 protein of the endocytotic machinery
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in cortex in FRAXA
    Susceptibility to psychotic bipolar disorder
    Variant & Polymorphism other variant increasing the risk of psychotic bipolar disorder
    Candidate gene candidate gene for susceptibility to schizophrenia
    Therapy target