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FLASH GENE
Symbol GPR180 contributors: np - updated : 13-12-2005
HGNC name G protein-coupled receptor 180
HGNC id 28899
Location 13q32.1      Physical location : 95.254.103 - 95.281.944
Synonym name
  • intimal thickness-related receptor
  • integral membrane protein GPR180
    • Synonym symbol(s) ITR
    DNA
    TYPE functioning gene
    STRUCTURE 27.00 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3922 49 440 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Reproductivefemale systemuteruscervix highly
    Respiratoryrespiratory tractlarynx  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a motif common to the Rhodopsin-like GPCR (G-protein-coupled receptor) superfamily
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to chimpanzee LOC467300
    ortholog to rattus MGC94555
    Homologene
    FAMILY
  • G protein-coupled receptor superfamily
    • CATEGORY regulatory , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • might playing an important role in the regulation of vascular remodeling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • a good target for development of drugs in the prevention of vascular restenosis
    • Marker
    Therapy target
    ANIMAL & CELL MODELS