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FLASH GENE

Symbol

GPN3

contributors: mct - updated : 05-01-2013

HGNC name	GPN-loop GTPase 3
HGNC id	30186

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q24.11      Physical location : 110.890.291 - 110.906.526
Synonym name	ATP binding domain 1 family, member C
	protein x 0004
Synonym symbol(s)	MGC14560, MGC32810, ATPBD1C, Parcs

DNA

TYPE	functioning gene
STRUCTURE	16.24 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001164372 8 - 1626 NP_001157844 - 323 - 2011 21768307 NM_016301 8 - 1505 NP_057385 - 284 - 2011 21768307 NM_001164373 8 - 1535 NP_001157845 - 294 - 2011 21768307

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel         Urinary bladder           kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

ortholog to murine Atpbd1c

Homologene

FAMILY	GPN-loop GTPase family
	small GTPases family

CATEGORY

enzyme , RNA associated

SUBCELLULAR LOCALIZATION

basic FUNCTION	GPN1/GPN3 define a new family of small GTPases that are specialized for the transport of RNA polymerase II into the nucleus
	plays a critical role in the nuclear accumulation of RNAP II, and this function explains potentially the relative importance of GPN3 in cell proliferation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP binding

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS