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Symbol GPN3 contributors: mct - updated : 05-01-2013
HGNC name GPN-loop GTPase 3
HGNC id 30186
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1626 - 323 - 2011 21768307
8 - 1505 - 284 - 2011 21768307
8 - 1535 - 294 - 2011 21768307
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel    
Urinarybladder    
 kidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Atpbd1c
Homologene
FAMILY
  • GPN-loop GTPase family
  • small GTPases family
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • GPN1/GPN3 define a new family of small GTPases that are specialized for the transport of RNA polymerase II into the nucleus
  • plays a critical role in the nuclear accumulation of RNAP II, and this function explains potentially the relative importance of GPN3 in cell proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS