| 1 | EIEE82, GOT1, GOT2
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| Bi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy.
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| van Karnebeek CDM, Ramos RJ, Wen XY, Tarailo-Graovac M, Gleeson JG, Skrypnyk C, Brand-Arzamendi K, Karbassi F, Issa MY, van der Lee R, Drögemöller BI, Koster J, Rousseau J, Campeau PM, Wang Y, Cao F, Li M, Ruiter J, Ciapaite J, Kluijtmans LAJ, Willemsen MAAP, Jans JJ, Ross CJ, Wintjes LT, Rodenburg RJ, Huigen MCDG, Jia Z, Waterham HR, Wasserman WW, Wanders RJA, Verhoeven-Duif NM, Zaki MS, Wevers RA.
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| Am J Hum Genet 105(3):534-548. doi: 10.1016/j.ajhg.2019.07.015. Epub 2019 Aug 15. 2019
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| 2 | GOT1, GOT2, HIF1A
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| HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis.
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| Meléndez-Rodríguez F, Urrutia AA, Lorendeau D, Rinaldi G, Roche O, Böğürcü-Seidel N, Ortega Muelas M, Mesa-Ciller C, Turiel G, Bouthelier A, Hernansanz-Agustín P, Elorza A, Escasany E, Li QOY, Torres-Capelli M, Tello D, Fuertes E, Fraga E, Martínez-Ruiz A, Pérez B, Giménez-Bachs JM, Salinas-Sánchez AS, Acker T, Sánchez Prieto R, Fendt SM, De Bock K, Aragonés J.
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| Cell Rep 26(9):2257-2265.e4. doi: 10.1016/j.celrep.2019.01.106.
2019
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| 3 | BRCA1, GOT1, GOT2
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| Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation.
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| Hong R, Zhang W, Xia X, Zhang K, Wang Y, Wu M, Fan J, Li J, Xia W, Xu F, Chen J, Wang S, Zhan Q.
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| Mol Oncol 13(4):959-977. doi: 10.1002/1878-0261.12466. Epub 2019 Mar 1.
2019
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| 4 | GOT1
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| Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.
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| Holt MC, Assar Z, Beheshti Zavareh R, Lin L, Anglin J, Mashadova O, Haldar D, Mullarky E, Kremer DM, Cantley LC, Kimmelman AC, Stein AJ, Lairson LL, Lyssiotis CA.
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| Biochemistry 57(47):6604-6614. doi: 10.1021/acs.biochem.8b00914. Epub 2018 Nov 12.
2018
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| 5 | GOT1
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| Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma.
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| Anglin J, Zavareh RB, Sander PN, Haldar D, Mullarky E, Cantley LC, Kimmelman AC, Lyssiotis CA, Lairson LL.
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| Bioorg Med Chem Lett 28(16):2675-2678. doi: 10.1016/j.bmcl.2018.04.061. Epub 2018 Apr 27.
2018
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| 6 | GOT1
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| Inhibition of glutamate oxaloacetate transaminase 1 in cancer cell lines results in altered metabolism with increased dependency of glucose.
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| Zhou X, Curbo S, Li F, Krishnan S, Karlsson A.
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| BMC Cancer 18(1):559. doi: 10.1186/s12885-018-4443-1.
2018
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| 7 | GOT1
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| A heterozygous mutation in GOT1 is associated with familial macro-aspartate aminotransferase.
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| Kulecka M, Wierzbicka A, Paziewska A, Mikula M, Habior A, Janczyk W, Dabrowska M, Karczmarski J, Lazniewski M, Ginalski K, Czlonkowska A, Socha P, Ostrowski J.
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| J Hepatol 67(5):1026-1030. doi: 10.1016/j.jhep.2017.07.003. Epub 2017 Jul 15.
2017
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| 8 | GOT1
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| GOT1-mediated anaplerotic glutamine metabolism regulates chronic acidosis stress in pancreatic cancer cells.
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| Abrego J, Gunda V, Vernucci E, Shukla SK, King RJ, Dasgupta A, Goode G, Murthy D, Yu F, Singh PK.
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| Cancer Lett 400:37-46. doi: 10.1016/j.canlet.2017.04.029. Epub 2017 Apr 26.
2017
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| 9 | GOT1
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| Expression, purification and preliminary crystallographic studies of human glutamate oxaloacetate transaminase 1 (GOT1).
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| Jiang X, Chang H, Zhou Y.
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| Protein Expr Purif 113:102-6. doi: 10.1016/j.pep.2015.05.010. Epub 2015 May 21.
2015
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| 10 | GOT1, KRAS
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| Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.
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| Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, DePinho RA, Cantley LC, Kimmelman AC.
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| Nature 496(7443):101-5. doi: 10.1038/nature12040. Epub 2013 Mar 27. Erratum in: Nature. 2013 Jul 25;499(7459):504.
2013
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| 11 | GOT1
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| Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels.
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| Shen H, Damcott C, Shuldiner SR, Chai S, Yang R, Hu H, Gibson Q, Ryan KA, Mitchell BD, Gong DW.
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| J Hum Genet 56(11):801-5. doi: 10.1038/jhg.2011.105. Epub 2011 Sep 8.
2011
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| 12 | GOT1
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| Multicopy suppressor analysis of thermosensitive YIP1 alleles implicates GOT1 in transport from the ER.
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| Lorente-Rodríguez A, Heidtman M, Barlowe C.
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| J Cell Sci 122(Pt 10):1540-50. Epub 2009 Apr 21.PMID: 19383723 2009
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| 13 | ETV6, GOT1
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| ETV6/GOT1 fusion in a case of t(10;12)(q24;p13)-positive myelodysplastic syndrome.
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| Struski S, Mauvieux L, Gervais C, Hélias C, Liu KL, Lessard M.
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| Haematologica 93(3):467-8.PMID: 18310541 2008
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| 14 | ETV6, GOT1
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| Fusion of ETV6 to GOT1 in a case with myelodysplastic syndrome and t(10;12)(q24;p13).
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| Janssen H, Wlodarska I, Mecucci C, Hagemeijer A, Vandenberghe P, Marynen P, Cools J.
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| Haematologica 91(7):949-51. Epub 2006 Jun 1.PMID: 16757412 2006
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| 15 | CNNM1, GOT1, UFS
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| High resolution mapping and mutation analyses of candidate genes in the urofacial syndrome (UFS) critical region.
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| Wang CY, Davoodi-Semiromi A, Shi JD, Yang P, Huang YQ, Agundez JA, Moran JM, Ochoa B, Hawkins-Lee B, She JX.
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| Am J Med Genet A 119A(1):9-14.PMID: 12707951 2003
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| 16 | GOT1, UFS
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| Genetic homogeneity, high-resolution mapping, and mutation analysis of the urofacial (Ochoa) syndrome and exclusion of the glutamate oxaloacetate transaminase gene (GOT1) in the critical region as the disease gene.
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| Wang CY, et al.
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| Am J Med Genet 84(5):454-9. 1999
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| 17 | ENTPD1, CYP2C@, DNTT, GOT1, IDE, IFIT1, PAX2, PDE6C, RBP4, WNT8B
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| An integrated physical and genetic map spanning chromosome band 10q24.
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| Gray IC, Fallowfield J, Ford S, Nobile C, Volpi EV, Spurr NK.
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| Genomics 43(1):85-8. 1997
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| 18 | GOT1, GOT2, GOT2P1, GOT2P2, GOT2P3
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| Chromosomal localization of human aspartate aminotransferase genes by in situ hybridization.
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| Pol S, et al.
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| Hum Genet 83 : 159-164. 1989
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| 19 | GOT1, PFKP
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| Confirmation of a de novo duplication, dup(10)(q24->q26), by GOT1 gene dosage studies.
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| Tomkins DJ, et al.
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| Hum Genet 63 : 369-373. 1983
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| 20 | GOT1, PGAM1
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| A further case of monosomy 10qter.
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| Evans-Jones G, et al.
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| Clin Genet 24 : 216-219. 1983
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| 21 | HK1, PPA1, GOT1
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| Refined mapping of GOT1, PP, and HK1 on chromosome 10.
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| Baeteman MA, et al.
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| Cytogenet Cell Genet 32 : 251. 1982
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| 22 | GOT1
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| Evidence of gene dosage effect for HK1 in the red cells of a patient with trisomy 10pter-p13.
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| Dallapicola B, et al.
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| Ann Genet 24 : 45-57. 1981
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| 23 | GOT1
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| Localisation de TGOs en 10q24-q262 et suggestion de localisation de HK-1 en 10q23.
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| Junien C, et al.
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| Ann Genet 22 : 50-52. 1979
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| 24 | GOT1
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| Gene dosage evidence for the regional assignment of the GOTs structural gene locus to 10q24-10q25.
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| Aitken DA, et al.
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| Cytogenet Cell Genet 22 : 468-471. 1978
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| 25 | GOT1
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| Assignment of the gene for cytoplasmic glutamic-oxaloacetic-transaminase to region q24-qter of human chromosome 10.
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| Chern CJ, et al.
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| Somatic Cell Genet 2 : 177-182. 1976
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