| basic FUNCTION
| catalyzing the condensation of glutamate and ammonia to form glutamine |
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involved in ammonia detoxification and interorgan nitrogen flux |
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strategic enzyme in controlling glutamate concentration in bone environment, decreasing the amount of this signalling molecule while vitamin D and WNT signalling pathway increased it  |
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can be found during early human fetal stages when it displays a significant effect on cell proliferation |
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its down-regulation may have an important pro-epileptogenic role in glioblastoma multiforme, through the slowing of glutamate-glutamine cycle |
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catalyzes the de novo synthesis of glutamine, an amino acid that has been shown to influence sperm motility |
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its presence in the post-acrosomal region of the perinuclear theca suggests that human sperm can carry out in glutamine synthesis |
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contributes to pancreatic regeneration |
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its expression is increased in regenerating hepatocytes and in early hepatocyte progenitor cells (HPCs) prior to morphological evidence of hepatocellular differentiation |
