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FLASH GENE
Symbol GLUL contributors: mct - updated : 09-12-2013
HGNC name glutamate-ammonia ligase (glutamine synthetase)
HGNC id 4341
ASSOCIATED DISORDERS
corresponding disease(s) GLUL
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in primary liver cancer
tumoral     --over  
in chronic hepatitis, focal nodular hyperplasia, peritumoural hyperplasia and some hepatocellular neoplasms
constitutional     --low  
in cirrhosis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
diabetetype 1 
can serve as novel targets in diabetes mellitus genetic therapy
cancerbrainglioma/neuroblstoma
manipulation of GLUL activity might constitute a novel principle for inhibiting seizures in patients with glioma epilepsy
ANIMAL & CELL MODELS