Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | GCLC | contributors: - updated : 25-11-2005 |
HGNC name | glutamate-cysteine ligase, catalytic subunit |
HGNC id | 4311 |
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Corresponding disease |
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Location | 6p12 Physical location : 53.362.139 - 53.409.831 | ||
Synonym name | gamma-glutamylcysteine synthetase,catalytic subunit | ||
Synonym symbol(s) | GCS, GLCL, GSH1 | ||
EC.number | 6.3.2.2 |
DNA |
TYPE | functioning gene |
STRUCTURE | 46.00 kb 16 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
constitutive of |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
| two subunits (heavy catalytic and light regulatory subunit) |
HOMOLOGY |
interspecies | homolog to murine Gclc |
Homologene |
FAMILY | glutamate cysteine ligase family 3 |
CATEGORY | enzyme |
SUBCELLULAR LOCALIZATION |
basic FUNCTION |
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule | metal binding, |
two metal binding sites |
protein |
cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) | GLCLC |
Susceptibility |
Variant & Polymorphism | association of polymorphism(-129C/T) with myocardial infarction |
Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |