Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GCLC contributors: - updated : 25-11-2005
HGNC name glutamate-cysteine ligase, catalytic subunit
HGNC id 4311
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticerythroid    
 spleen    
 thymus    
Cardiovascularheart    
Digestiveliver    
Nervousspinal cord    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialsecretoryglandularexocrine 
Muscularstriatumcardiac  
Muscularstriatumskeletal  
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two subunits (heavy catalytic and light regulatory subunit)
HOMOLOGY
interspecies homolog to murine Gclc
Homologene
FAMILY glutamate cysteine ligase family 3
CATEGORY enzyme
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • catalyzing and limiting the first step of GSH synthesis, gamma-glutamyl cycle
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    two metal binding sites
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GLCLC
    Susceptibility
    Variant & Polymorphism association of polymorphism(-129C/T) with myocardial infarction
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS