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FLASH GENE
Symbol GCLC contributors: - updated : 25-11-2005
HGNC name glutamate-cysteine ligase, catalytic subunit
HGNC id 4311
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two subunits (heavy catalytic and light regulatory subunit)
HOMOLOGY
interspecies homolog to murine Gclc
Homologene
FAMILY glutamate cysteine ligase family 3
CATEGORY enzyme
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • catalyzing and limiting the first step of GSH synthesis, gamma-glutamyl cycle
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    two metal binding sites
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GLCLC
    Susceptibility
    Variant & Polymorphism association of polymorphism(-129C/T) with myocardial infarction
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS