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FLASH GENE
Symbol GABRE contributors: - updated : 11-02-2004
HGNC name gamma-aminobutyric acid (GABA) A receptor, epsilon
HGNC id 4085
Location Xq28      Physical location : 151.121.596 - 151.143.151
Genatlas name ionotropic,clustered with GABRA3 and GABRB4
Synonym symbol(s) GAE
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text clustered with GABRA3, GABRB4 and GABRQ
STRUCTURE 21.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map see GABRA3
Physical map
LOC392557 X similar to hypothetical protein GPR50 Xq28 G protein-coupled receptor 50 LOC286456 Xq28 similar to NGFI-A binding protein 1; NGFI-A-binding protein 1; EGR1 binding protein 1 LOC139135 Xq28 hypothetical protein LOC139135 TMG3 Xq28 transmembrane gamma-carboxyglutamic acid protein 3 FATE Xq28 transmembrane gamma-carboxyglutamic acid protein 3 LOC389902 X similar to Cyclic-nucleotide-gated olfactory channel (Cyclic-nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2) (Aorta CNG channel) (RACNG) MAGEA4 Xq28 melanoma antigen, family A, 4 GABRE Xq28 gamma-aminobutyric acid (GABA) A receptor, epsilon LOC392558 X similar to 33K laminin receptor homolog - bovine MAGEA5 Xq28 melanoma antigen, family A, 5 MAGEA10 Xq28 melanoma antigen, family A, 10 GABRA3 Xq28 gamma-aminobutyric acid (GABA) A receptor, alpha 3 GABRQ Xq28 gamma-aminobutyric acid (GABA) receptor, theta TRAG3 Xq28 taxol resistance associated gene 3 MAGEA2b Xq28 melanoma antigen, family A, 2, copy b MAGEA12 Xq28 melanoma antigen, family A, 12 CSAGE Xq28 chondrosarcoma associated gene 1 MAGEA2 Xq28 melanoma antigen, family A, 2 LOC389903 X similar to Taxol resistant associated protein 3 (TRAG-3) MAGEA3 Xq28 melanoma antigen, family A, 3 MAGEA6 Xq28 melanoma antigen, family A, 6 psMAGEA Xq28 melanoma antigen pseudogene, family A
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 3152 - 506 - Davies
- - 3329 - 393 - Davies
- - 3233 - 361 - Davies
- - 4066 - 393 - Davies
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain    
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a ligand binding site in the N terminal region, four transmembrane segments,one of which forming the wall of the channel and a large intracellular loop
mono polymer pentamer
HOMOLOGY
interspecies homolog to murine Gabre
Homologene
FAMILY ligand gated ionic channel family
CATEGORY receptor membrane ligand ion channel
SUBCELLULAR LOCALIZATION
basic FUNCTION multisubunit chloride channel mediating the fastest inhibitory synaptic transmission in the central nervous system.
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component component of a pentameric receptor mediating inhibitory neurotransmission
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
ANIMAL & CELL MODELS