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FLASH GENE
Symbol G6PC3 contributors: mct/npt - updated : 15-05-2012
HGNC name glucose 6 phosphatase, catalytic, 3
HGNC id 24861
Corresponding disease
SCNP4 severe congenital neutropenia 4
Location 17q21.31      Physical location : 42.148.097 - 42.153.711
Synonym name
  • glucose-6-phosphatase catalytic subunit 3
  • ubiquitously expressed G6Pase catalytic subunit-related protein
  • G-6-Pase 3
  • Synonym symbol(s) UGRP, PAP2.8, G6Pase-beta
    EC.number 3.1.3.9
    DNA
    TYPE functioning gene
    STRUCTURE 5.61 kb     6 Exon(s)
    regulatory sequence Promoter
    text structure promoter was highly active in all cell lines examined.
    MAPPING cloned Y linked N status provisional
    Physical map
    NBR2 17q21 neighbor of BRCA1 gene 2 LOC387620 17 membrane component, chromosome 17, surface marker 2 MGC20235 17q21.31 hypothetical protein MGC20235 LOC388388 17 LOC388388 RNU2P2 17q21.31 RNA, U2 small nuclear pseudogene 2 ARF4L 17q12-q21 ADP-ribosylation factor 4-like LOC284064 17q21.31 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) DHX8 17q21.31 DEAH (Asp-Glu-Ala-His) box polypeptide 8 ETV4 17q21 ets variant gene 4 (E1A enhancer binding protein, E1AF) MEOX1 17q21 mesenchyme homeo box 1 LOC390797 17 similar to WHSC1L1 protein isoform long; Wolf-Hirschhorn syndrome candidate 1-like 1 protein SOST 17q12-q21 sclerosteosis DUSP3 17q21 dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) LOC284067 17q21.31 hypothetical LOC284067 MPP3 17q12-q21 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) TREM4 17q21.31 triggering receptor expressed on myeloid cells 4 MPP2 17q12-q21 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) APR-2 17q21.31 apoptosis related protein LOC390798 17 similar to wingless-type MMTV integration site family, member 9B precursor; wingless-type MMTV integration site family, member 15 PPY 17q21.2 pancreatic polypeptide PYY 17q21.1 peptide YY NAGS 17q21.31 peptide YY MGC4251 17q21.31 hypothetical protein MGC4251 FLJ30656 17q21.31 hypothetical protein FLJ30656 G6PC3 17q21.31 glucose-6-phosphatase catalytic subunit 3 HDAC5 17q21 histone deacetylase 5 MGC3130 17q21.31 hypothetical protein MGC3130 ASB16 17q21.31 ankyrin repeat and SOCS box-containing 16 DKFZp762C2414 17q21.31 hypothetical protein DKFZp762C2414 MGC3123 17q21.31 hypothetical protein MGC3123 UBTF 17q21.3 upstream binding transcription factor, RNA polymerase I LOC390799 17 similar to SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1 SLC4A1 17q21-q22 solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) RPIP8 17p13.2 solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) CGI-69 17q12 CGI-69 protein GRN 17q21.3 granulin MGC34829 17q21.31 Similar to hypothetical gene supported by AL050367; AK022946 LOC390800 17 similar to ribosomal protein L7-like 1 ITGA2B 17q21.32 integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) KIAA0553 17q21.31 KIAA0553 protein FZD2 17q21.1 frizzled homolog 2 (Drosophila) FLJ35848 17q21.31 hypothetical protein FLJ35848 FLJ31795 17q21.31 hypothetical protein FLJ31795 DRF1 17q21.31 Dbf4-related factor 1 ADAM11 17q21.3 a disintegrin and metalloproteinase domain 11 GJA7 17q21.31 gap junction protein, alpha 7, 45kDa (connexin 45) CLST11240 17q21.31 CLST 11240 protein U5-116KD 17q21.31 U5 snRNP-specific protein, 116 kD LOC388389 17 similar to RIKEN cDNA 4933439F11 GFAP 17q21.1 glial fibrillary acidic protein LOC146909 17q21.31 hypothetical protein LOC146909 CRF 17q21 C1q-related factor
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1654 38.6 346 - 2003 12965222
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain   predominantly
     nerve   highly
    Reproductivefemale systemovary  highly
     female systemuteruscervix highly
    Visualeyelens   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • glucose-6-phosphatase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • key enzyme in homeostatic regulation of blood glucose levels
  • preferentially hydrolyzed other substrates including pNPP and 2-deoxy-glucose-6-phosphate compared to the liver enzyme
  • catalyzes hydrolysis of G6P to glucose and phosphate, the last step of the gluconeogenic and glycogenolytic pathways
  • major glucose-6-phosphatase of physiological importance for glucose homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other its regulation is sensitive to carbohydrate, but not to fatty acid metabolites, and at much lower physiological concentrations
    ASSOCIATED DISORDERS
    corresponding disease(s) SCNP4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    results in lowered plasma cholesterol and elevated glucagon
    constitutional     --low  
    reduced G6PC3 expression could occur during hypoglycemic episodes, which are common in utero and in the postnatal period
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS