Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol G6PC3 contributors: mct/npt - updated : 15-05-2012
HGNC name glucose 6 phosphatase, catalytic, 3
HGNC id 24861
Corresponding disease
SCNP4 severe congenital neutropenia 4
Location 17q21.31      Physical location : 42.148.097 - 42.153.711
Synonym name
  • glucose-6-phosphatase catalytic subunit 3
  • ubiquitously expressed G6Pase catalytic subunit-related protein
  • G-6-Pase 3
  • Synonym symbol(s) UGRP, PAP2.8, G6Pase-beta
    EC.number 3.1.3.9
    DNA
    TYPE functioning gene
    STRUCTURE 5.61 kb     6 Exon(s)
    regulatory sequence Promoter
    text structure promoter was highly active in all cell lines examined.
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1654 38.6 346 - 2003 12965222
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain   predominantly
     nerve   highly
    Reproductivefemale systemovary  highly
     female systemuteruscervix highly
    Visualeyelens   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • glucose-6-phosphatase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • key enzyme in homeostatic regulation of blood glucose levels
  • preferentially hydrolyzed other substrates including pNPP and 2-deoxy-glucose-6-phosphate compared to the liver enzyme
  • catalyzes hydrolysis of G6P to glucose and phosphate, the last step of the gluconeogenic and glycogenolytic pathways
  • major glucose-6-phosphatase of physiological importance for glucose homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other its regulation is sensitive to carbohydrate, but not to fatty acid metabolites, and at much lower physiological concentrations
    ASSOCIATED DISORDERS
    corresponding disease(s) SCNP4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    results in lowered plasma cholesterol and elevated glucagon
    constitutional     --low  
    reduced G6PC3 expression could occur during hypoglycemic episodes, which are common in utero and in the postnatal period
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS