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FLASH GENE
Symbol G6PC3 contributors: mct/npt - updated : 15-05-2012
HGNC name glucose 6 phosphatase, catalytic, 3
HGNC id 24861
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • glucose-6-phosphatase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • key enzyme in homeostatic regulation of blood glucose levels
  • preferentially hydrolyzed other substrates including pNPP and 2-deoxy-glucose-6-phosphate compared to the liver enzyme
  • catalyzes hydrolysis of G6P to glucose and phosphate, the last step of the gluconeogenic and glycogenolytic pathways
  • major glucose-6-phosphatase of physiological importance for glucose homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other its regulation is sensitive to carbohydrate, but not to fatty acid metabolites, and at much lower physiological concentrations
    ASSOCIATED DISORDERS
    corresponding disease(s) SCNP4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    results in lowered plasma cholesterol and elevated glucagon
    constitutional     --low  
    reduced G6PC3 expression could occur during hypoglycemic episodes, which are common in utero and in the postnatal period
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS