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FLASH GENE
Symbol FXYD2 contributors: npt/ - updated : 09-03-2006
HGNC name FXYD domain containing ion transport regulator 2
HGNC id 4026
Corresponding disease
HOMG2 renal hypomagnesemia, 2
Location 11q23.3      Physical location : 117.690.789 - 117.698.807
Synonym name
  • ATPase,Na+/K+ transporting gamma 1 polypeptide
  • sodium-potassium-ATPase, gamma polypeptide
  • Na(+)/K(+) ATPase subunit gamma
  • Synonym symbol(s) ATP1G1, ATNG
    DNA
    TYPE functioning gene
    STRUCTURE 8.02 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure consensus binding site for transcription factor sp1
    MAPPING cloned Y linked N status confirmed
    Map D11S939 - FXYD2 - D11S4127 - qter
    Authors Monnens (00)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 initiation site 591 - 64 - -
    2 - 2747 - 145 - -
    6 - 584 - 66 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Urinarykidney   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinaryepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 35 AA signature with the PFXYD motif at the beginning
  • a cytoplasmic positively charged C terminus
  • secondary structure alpha (catalytic) beta and gamma subunit
    conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Fxyd2
    Homologene
    FAMILY
  • FXYD2 family
  • CATEGORY regulatory , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text basolateral membrane
    basic FUNCTION
  • regulatory subunit of Na,K-ATPase in the kidney, pancreas, liver
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HOMG2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS