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FLASH GENE
Symbol FRMPD4 contributors: mct - updated : 31-10-2012
HGNC name FERM and PDZ domain containing 4
HGNC id 29007
Location Xp22.2      Physical location : 12.156.584 - 12.742.636
Synonym name
  • cDNA sequence,expressed in brain,>100kDa
  • PDZ domain containing 10
  • Preso, PSD-95-interacting regulator of spine morphogenesis
  • Synonym symbol(s) KIAA0316, PDZK10, PDZD10, Preso
    DNA
    TYPE functioning gene
    STRUCTURE 586.06 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 8477 - 1322 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Nervousbrain   moderately Homo sapiens
    Reproductivefemale systembreastmammary gland  
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervous    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • WW (domain with two conserved Trp residues)
  • PDZ (PSD-95/Dlg/ZO-1), FERM (4.1, ezrin, radixin, and moesin), and C-terminal PDZ-binding domains
  • HOMOLOGY
    interspecies homolog to murine Frmpd4 (90.7pc)
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • positively regulates spine density through its interaction with the synaptic plasma membrane, actin filaments, DLG4, and the ARHGEF7-based RAC1 signaling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • formed a complex with ARHGEF7 via DLG4/Dlg/TJP1 (PDZ) interaction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DLG4 -interacting protein
  • INPP5J is a key signalling molecule that regulates dendritic outgrowth through activation of small GTPase signalling via interaction between FRMPD4 and ARHGEF7
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS