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FLASH GENE
Symbol FRMPD4 contributors: mct - updated : 31-10-2012
HGNC name FERM and PDZ domain containing 4
HGNC id 29007
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 8477 - 1322 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid    
Nervousbrain   moderately Homo sapiens
Reproductivefemale systembreastmammary gland  
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervous    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • WW (domain with two conserved Trp residues)
  • PDZ (PSD-95/Dlg/ZO-1), FERM (4.1, ezrin, radixin, and moesin), and C-terminal PDZ-binding domains
  • HOMOLOGY
    interspecies homolog to murine Frmpd4 (90.7pc)
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • positively regulates spine density through its interaction with the synaptic plasma membrane, actin filaments, DLG4, and the ARHGEF7-based RAC1 signaling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • formed a complex with ARHGEF7 via DLG4/Dlg/TJP1 (PDZ) interaction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DLG4 -interacting protein
  • INPP5J is a key signalling molecule that regulates dendritic outgrowth through activation of small GTPase signalling via interaction between FRMPD4 and ARHGEF7
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS