Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FRMPD4 contributors: mct - updated : 31-10-2012
HGNC name FERM and PDZ domain containing 4
HGNC id 29007
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • WW (domain with two conserved Trp residues)
  • PDZ (PSD-95/Dlg/ZO-1), FERM (4.1, ezrin, radixin, and moesin), and C-terminal PDZ-binding domains
  • HOMOLOGY
    interspecies homolog to murine Frmpd4 (90.7pc)
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • positively regulates spine density through its interaction with the synaptic plasma membrane, actin filaments, DLG4, and the ARHGEF7-based RAC1 signaling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • formed a complex with ARHGEF7 via DLG4/Dlg/TJP1 (PDZ) interaction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DLG4 -interacting protein
  • INPP5J is a key signalling molecule that regulates dendritic outgrowth through activation of small GTPase signalling via interaction between FRMPD4 and ARHGEF7
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS