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FLASH GENE
Symbol FDX1 contributors: mct - updated : 20-11-2017
HGNC name ferredoxin 1
HGNC id 3638
Location 11q22.3      Physical location : 110.300.593 - 110.335.604
Synonym name
  • adrenodoxin
  • hepatoredoxin
  • adrenal ferredoxin
  • mitochondrial adrenodoxin
  • Synonym symbol(s) ADX, FDX, YAH1, LOH11CR1D
    DNA
    TYPE functioning gene
    STRUCTURE 35.01 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - (D11S384 /ACAT1 ) - D11S535 ,D11S2179 - D11S1294 - D11S2180 ,D11S1818 - D11S1897 - D11S2021 - D11S927 - D11S1300 - FDX1 - D11S1391 - D11S1893 - D11S996E , CRYAB , D11S1347 - D11S424 - D11S897 - NCAM1 - qter
    Authors Arai (96)
    Physical map
    HCP29 11q22.3 cytochrome c, somatic pseudogene LOC260340 11q23.1 processed pseudogene mtTFA 2 LOC390249 11 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) LOC390250 11 similar to RPB5_Human KIAA1726 11q23.1 KIAA1726 protein RDX 11q22.3-q23.1 radixin FDX1 11q22.3-q23.1 ferredoxin 1 ARHGAP20 11q23.2 Rho GTPase activating protein 20 LOC120364 11q23.2 similar to Hnrpa1 protein MGC50104 11q23.2 Similar to RIKEN cDNA 1810046K07 gene LOC120376 11q23.2 hypothetical protein LOC120376 POU2AF1 11q23.1 POU domain, class 2, associating factor 1 BTG4 11q23.2-q23.3 B-cell translocation gene 4 LOC387807 11 hypothetical gene supported by AK128145; BC039505 LOC143903 11q23.2 layilin SIK2 11q23.2 salt-inducible serine/threonine kinase 2 PPP2R1B 11q23 protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform DIBD1 11q23 disrupted in bipolar affective disorder 1 C11orf1 11p15.5 chromosome 11 open reading frame 1 CRYAB 11q22.3-q23.1 crystallin, alpha B HSPB2 11q22.3-q23.1 heat shock 27kDa protein 2 MGC14839 11q23.2 similar to RIKEN cDNA 2310030G06 gene DIXDC1  DIX domain containing 1 LOC387808 11 similar to KIAA1735 protein DLAT 11q23.1 dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) LOC246731 11q23 peptidyl prolyl isomerase H (cyclophilin H) pseudogene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3236 5.85 184 - 2015 26370181
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 2fe-2s ferredoxin-type domain
  • HOMOLOGY
    Homologene
    FAMILY
  • adrenodoxin/putidaredoxin family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,nucleus
    text
  • present in the matrix of human mitochondria
  • basic FUNCTION
  • small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to a terminal cytochrome P450
  • mitochondrial electron transfer protein, is able to support reactions catalyzed by human microsomal P450 (Pechurskaya 2007)
  • participating in the synthesis of thyroid hormones
  • able to reduce mitochondrial cytochrome P450 (Sheftel 2010)
  • can only reduce mitochondrial CYP enzymes that are essential in adrenal steroidogenesis, bile acid formation, and vitamin D synthesis (Sheftel 2010)
  • is an iron-sulfur protein that is involved in various metabolic processes, including steroid hormone synthesis in mammalian tissues
  • transcription of FDX1 is regulated by the NR5A family and cAMP signaling, and participates in steroid hormone production in ovarian granulosa cells
  • TNFSF13 and FDX1 have potential roles in IgA nephropathy (IgAN)
  • FDX1L, FDX1, play an important role as an electron donor in iron-sulfur (Fe-S) cluster biosynthesis
  • FDX1L, FDX1 can function in Fe-S cluster assembly
  • has an only weak effect on ferric and ferrous CO states, but it has a relatively stronger impact on the Fe-O-O fragments of the functionally relevant oxy complexes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binds 1 2fe-2s cluster
  • protein
  • interference with any of the three related genes, FDX1, FDX1L or FDXR, disrupts iron-sulfur cluster assembly and maintenance of normal cytosolic and mitochondrial iron homeostasis
  • NR5A1 could bind to the FDX1 promoter in differentiated hMSCs
  • supports steroid biosynthesis in steroidogenic cells through electron transfer to the rate-limiting steroidogenic enzyme, CYP11A1
  • mitochondrial cytochrome P450s require adrenodoxin (FDX1) and adrenodoxin reductase (FDXR)
  • JUN may cooperate with other partners to regulate FDX1 in Leydig cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS