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FLASH GENE

Symbol

EXOC7

contributors: mct - updated : 27-04-2015

HGNC name	exocyst complex component 7
HGNC id	23214

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q25.1      Physical location : 74.077.086 - 74.099.868
Synonym name	murine exo70 protein homolog
	exocyst complex component Exo70
Synonym symbol(s)	KIAA1067, EX070, Exo70p, YJL085W, EXO70, 2-5-3p, DKFZp686J04253, EXOC1, FLJ40965, FLJ46415, YJL085W

DNA

TYPE	functioning gene
STRUCTURE	22.79 kb     20 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001013839 19 - 4799 NP_001013861 - 684 - 2005 15705715 isoform 1 NM_001145297 20 - 4952 NP_001138769 - 735 - 2005 15705715 isoform 4 NM_001145298 19 - 4775 NP_001138770 - 676 - 2005 15705715 isoform 5 NM_001145299 20 - 4868 NP_001138771 - 707 - 2005 15705715 isoform 6 NM_015219 18 - 4706 NP_056034 - 653 - 2005 15705715 isoform 2 NM_001282313 19 - 4834 NP_001269242 - 656 - - NM_001282314 - - 771 NP_001269243 - 159 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       lowly Nervous brain diencephalon amygdala

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	liver, brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to murine Exoc7 (95.9pc)
	homolog to rattus Exoc7 (96.6pc)

Homologene

FAMILY	EXO70 family
	ligand-gated ionic channel family

CATEGORY

transport

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	translocates to the plasma membrane in resposne to insulin through the activation of RHOQ

basic FUNCTION	required for exocytosis
	involved in the target of secretory vesicles at specific domains of the plasma membrane for cell surface expression and protein secretion
	assembles a multiprotein complex that includes EXOC3 and EXOC4
	in adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in resposne to insulin
	in addition to functioning in exocytosis, EXOC7 also regulates actin at the leading edges of migrating cells and therefore coordinates cytoskeleton and membrane traffic during cell migration
	RHOQ and EXOC7 are essential for the polarized externalization of IGF1 receptor, and this process is necessary for axon specification
	role in nuclear mRNA splicing, where it might signal membrane events to the splicing apparatus

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

exocytosis transport

PATHWAY

metabolism

signaling

a component

component of the exocyst complex (EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7, EXOC8) involved in the docking of exocystic vesicles with fusion sites on the plasma membrane

INTERACTION

DNA

RNA

small molecule

protein	interacting with ARGEF2 in trans-golgi network and centrosome
	interacting with RHOQ in a GTP-dependent manner
	interacting with RAB11FIP3
	interacts directly with PRPF19 and shuttles to the nucleus, where it associates with the spliceosome
	PIP5K1C associates with the exocyst via a direct interaction with EXOC7, the exocyst subunit that guides the polarized targeting of exocyst to the plasma membrane
	effect of EXOC7 on actin is mediated by promoting the interaction of the Arp2/3 complex with WASF2, a member of the N-WASP/WAVE family of nucleation promoting factors
	directly interacts with the Arp2/3 complex, a core nucleating factor for the generation of branched actin networks for cell morphogenesis and migration

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS