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FLASH GENE
Symbol EXOC7 contributors: mct - updated : 27-04-2015
HGNC name exocyst complex component 7
HGNC id 23214
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
HOMOLOGY
interspecies homolog to murine Exoc7 (95.9pc)
homolog to rattus Exoc7 (96.6pc)
Homologene
FAMILY
  • EXO70 family
  • ligand-gated ionic channel family
    • CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text translocates to the plasma membrane in resposne to insulin through the activation of RHOQ
    basic FUNCTION
  • required for exocytosis
  • involved in the target of secretory vesicles at specific domains of the plasma membrane for cell surface expression and protein secretion
  • assembles a multiprotein complex that includes EXOC3 and EXOC4
  • in adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in resposne to insulin
  • in addition to functioning in exocytosis, EXOC7 also regulates actin at the leading edges of migrating cells and therefore coordinates cytoskeleton and membrane traffic during cell migration
  • RHOQ and EXOC7 are essential for the polarized externalization of IGF1 receptor, and this process is necessary for axon specification
  • role in nuclear mRNA splicing, where it might signal membrane events to the splicing apparatus
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of the exocyst complex (EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7, EXOC8) involved in the docking of exocystic vesicles with fusion sites on the plasma membrane
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ARGEF2 in trans-golgi network and centrosome
  • interacting with RHOQ in a GTP-dependent manner
  • interacting with RAB11FIP3
  • interacts directly with PRPF19 and shuttles to the nucleus, where it associates with the spliceosome
  • PIP5K1C associates with the exocyst via a direct interaction with EXOC7, the exocyst subunit that guides the polarized targeting of exocyst to the plasma membrane
  • effect of EXOC7 on actin is mediated by promoting the interaction of the Arp2/3 complex with WASF2, a member of the N-WASP/WAVE family of nucleation promoting factors
  • directly interacts with the Arp2/3 complex, a core nucleating factor for the generation of branched actin networks for cell morphogenesis and migration
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS