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FLASH GENE
Symbol EXOC7 contributors: mct - updated : 27-04-2015
HGNC name exocyst complex component 7
HGNC id 23214
DNA
TYPE functioning gene
STRUCTURE 22.79 kb     20 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 4799 - 684 - 2005 15705715
isoform 1
20 - 4952 - 735 - 2005 15705715
isoform 4
19 - 4775 - 676 - 2005 15705715
isoform 5
20 - 4868 - 707 - 2005 15705715
isoform 6
18 - 4706 - 653 - 2005 15705715
isoform 2
19 - 4834 - 656 - -
- - 771 - 159 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   lowly
Nervousbraindiencephalonamygdala  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver, brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
HOMOLOGY
interspecies homolog to murine Exoc7 (95.9pc)
homolog to rattus Exoc7 (96.6pc)
Homologene
FAMILY
  • EXO70 family
  • ligand-gated ionic channel family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text translocates to the plasma membrane in resposne to insulin through the activation of RHOQ
    basic FUNCTION
  • required for exocytosis
  • involved in the target of secretory vesicles at specific domains of the plasma membrane for cell surface expression and protein secretion
  • assembles a multiprotein complex that includes EXOC3 and EXOC4
  • in adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in resposne to insulin
  • in addition to functioning in exocytosis, EXOC7 also regulates actin at the leading edges of migrating cells and therefore coordinates cytoskeleton and membrane traffic during cell migration
  • RHOQ and EXOC7 are essential for the polarized externalization of IGF1 receptor, and this process is necessary for axon specification
  • role in nuclear mRNA splicing, where it might signal membrane events to the splicing apparatus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of the exocyst complex (EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7, EXOC8) involved in the docking of exocystic vesicles with fusion sites on the plasma membrane
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ARGEF2 in trans-golgi network and centrosome
  • interacting with RHOQ in a GTP-dependent manner
  • interacting with RAB11FIP3
  • interacts directly with PRPF19 and shuttles to the nucleus, where it associates with the spliceosome
  • PIP5K1C associates with the exocyst via a direct interaction with EXOC7, the exocyst subunit that guides the polarized targeting of exocyst to the plasma membrane
  • effect of EXOC7 on actin is mediated by promoting the interaction of the Arp2/3 complex with WASF2, a member of the N-WASP/WAVE family of nucleation promoting factors
  • directly interacts with the Arp2/3 complex, a core nucleating factor for the generation of branched actin networks for cell morphogenesis and migration
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS