| 1 | ETS1, ETS2
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| Transcription factor Ets1, but not the closely related factor Ets2, inhibits antibody-secreting cell differentiation.
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| John S, Russell L, Chin SS, Luo W, Oshima R, Garrett-Sinha LA.
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| Mol Cell Biol 34(3):522-32. doi: 10.1128/MCB.00612-13. Epub 2013 Nov 25.
2014
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| 2 | ETS2, STAB1
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| Extracellular low pH modulates phosphatidylserine-dependent phagocytosis in macrophages by increasing stabilin-1 expression.
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| Park SY, Bae DJ, Kim MJ, Piao ML, Kim IS.
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| J Biol Chem 287(14):11261-71. doi: 10.1074/jbc.M111.310953. Epub 2012 Feb 10.
2012
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| 3 | ETS2, MESP1
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| Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors.
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| Islas JF, Liu Y, Weng KC, Robertson MJ, Zhang S, Prejusa A, Harger J, Tikhomirova D, Chopra M, Iyer D, Mercola M, Oshima RG, Willerson JT, Potaman VN, Schwartz RJ.
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| Proc Natl Acad Sci U S A 109(32):13016-21. doi: 10.1073/pnas.1120299109. Epub 2012 Jul 23.
2012
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| 4 | ETS2
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| Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis.
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| Birsoy K, Berry R, Wang T, Ceyhan O, Tavazoie S, Friedman JM, Rodeheffer MS.
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| Development. 138(21):4709-19. 2011
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| 5 | ELF1, ETS1, ETS2, FLI1
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| The mouse and human Fli1 genes are similarly regulated by Ets factors in T cells.
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| Svenson JL, Chike-Harris K, Amria MY, Nowling TK.
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| Genes Immun 11(2):161-72. Epub 2009 Oct 15.PMID: 19829305 2010
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| 6 | DUSP6, ETS2, MAPK1
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| Feedback regulation of DUSP6 transcription responding to MAPK1 via ETS2 in human cells.
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| Furukawa T, Tanji E, Xu S, Horii A.
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| Biochem Biophys Res Commun 377(1):317-20. Epub 2008 Oct 9. 2008
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| 7 | ETS2
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| Ets2 is required for trophoblast stem cell self-renewal.
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| Wen F, Tynan JA, Cecena G, Williams R, Múnera J, Mavrothalassitis G, Oshima RG.
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| Dev Biol. 312(1):284-99. 2007
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| 8 | ETS2
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| Associations and interactions between Ets-1 and Ets-2 and coregulatory proteins, SRC-1, AIB1, and NCoR in breast cancer.
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| Myers E, Hill AD, Kelly G, McDermott EW, O'Higgins NJ, Buggy Y, Young LS.
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| Clin Cancer Res. 11(6):2111-22. 2005
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| 9 | C21orf24, ERG, ETS2
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| Detailed mapping of the ERG-ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16.
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| Owczarek CM, Portbury KJ, Hardy MP, O'Leary DA, Kudoh J, Shibuya K, Shimizu N, Kola I, Hertzog PJ.
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| Gene 324:65-77. 2004
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| 10 | CREBBP, NCOA1, ETS2, TP53, IRF3, EP300
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| A Conserved alpha-helical motif mediates the binding of diverse nuclear proteins to the SRC1 interaction domain of CBP.
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| Matsuda S, Harries JC, Viskaduraki M, Troke PJ, Kindle KB, Ryan C, Heery DM.
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| J Biol Chem 279(14):14055-64. Epub 2004 Jan 13. 2004
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| 11 | DCR, ETS2
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| ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway
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| Wolvetang EJ, Wilson TJ, Sanij E, Busciglio J, Hatzistavrou T, Seth A, Hertzog PJ, Kola I.
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| Hum Mol Genet 12(3):247-55. 2003
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| 12 | ETS2
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| Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis.
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| Wolvetang EJ, Bradfield OM, Hatzistavrou T, Crack PJ, Busciglio J, Kola I, Hertzog PJ.
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| Neurobiol Dis 14(3):349-56. 2003
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| 13 | ETS2, APP
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| The chromosome 21 transcription factor ETS2 transactivates the beta-APP promoter: implications for Down syndrome.
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| Wolvetang EW, Bradfield OM, Tymms M, Zavarsek S, Hatzistavrou T, Kola I, Hertzog PJ.
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| Biochim Biophys Acta 1628(2):105-10. 2003
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| 14 | ETS2, ZMYND11
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| Ets-2 interacts with co-repressor BS69 to repress target gene expression.
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| Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC.
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| Anticancer Res 23(3A):2173-8. 2003
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| 15 | ETS1, ETS2, TDP2
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| EAPII interacts with ETS1 and modulates its transcriptional function.
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| Pei H, Yordy JS, Leng Q, Zhao Q, Watson DK, Li R.
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| Oncogene 22(18):2699-709. 2003
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| 16 | BRCA1, ETS2
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| Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter.
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| Baker KM, Wei G, Schaffner AE, Ostrowski MC.
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| J Biol Chem. 278(20):17876-84. 2003
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| 17 | ETS2
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| ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway.
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| Wolvetang EJ, Wilson TJ, Sanij E, Busciglio J, Hatzistavrou T, Seth A, Hertzog PJ, Kola I.
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| Hum Mol Genet. 12(3):247-55. 2003
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| 18 | CDKN2A, ETS1, ETS2, ID1
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| Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence.
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| Ohtani N, Zebedee Z, Huot TJ, Stinson JA, Sugimoto M, Ohashi Y, Sharrocks AD, Peters G, Hara E.
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| Nature 409(6823):1067-70. 2001
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| 19 | ETS2
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| Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity.
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| Kasten M, Giordano A.
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| Oncogene. 20(15):1832-8. 2001
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| 20 | ETS2
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| Physical interaction and functional synergy between glucocorticoid receptor and Ets2 proteins for transcription activation of the rat cytochrome P-450c27 promoter.
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| Mullick J, Anandatheerthavarada HK, Amuthan G, Bhagwat SV, Biswas G, Camasamudram V, Bhat NK, Reddy SE, Rao V, Avadhani NG.
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| J Biol Chem. 276(21):18007-17. 2001
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| 21 | ETS2
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| Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene.
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| Pastorcic M, Das HK.
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| J Biol Chem. 275(45):34938-45. 2000
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| 22 | ETS2
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| IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells.
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| Rameil P, Lécine P, Ghysdael J, Gouilleux F, Kahn-Perlès B, Imbert J.
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| Oncogene. 19(17):2086-97. 2000
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| 23 | DCR, ETS2
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| Evidence against the current hypothesis of gene dosage effects of trisomy 21: ets-2, encoded on chromosome 21 is not overexpressed in hearts of patients with Down Syndrome.
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| Greber-Platzer S, et al.
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| Biochem Biophys Res Commun 254(2):395-9. 1999
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| 24 | EHF, ETS2
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| Human chromosomal localization, tissue/tumor expression, and regulatory function of the ets family gene EHF.
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| Kleinbaum LA, Duggan C, Ferreira E, Coffey GP, Buttice G, Burton FH.
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| Biochem Biophys Res Commun 264(1):119-26 1999
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| 25 | ETS2
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| p300/cAMP-responsive element-binding protein interactions with ets-1 and ets-2 in the transcriptional activation of the human stromelysin promoter.
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| Jayaraman G, Srinivas R, Duggan C, Ferreira E, Swaminathan S, Somasundaram K, Williams J, Hauser C, Kurkinen M, Dhar R, Weitzman S, Buttice G, Thimmapaya B.
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| J Biol Chem. 274(24):17342-52. 1999
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| 26 | ETS2
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| Regulation of the human interleukin-5 promoter by Ets transcription factors. Ets1 and Ets2, but not Elf-1, cooperate with GATA3 and HTLV-I Tax1.
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| Blumenthal SG, Aichele G, Wirth T, Czernilofsky AP, Nordheim A, Dittmer J.
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| J Biol Chem. 274(18):12910-6. 1999
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| 27 | PSMG1, SH3BGR, ETS2
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| High resolution physical mapping and identification of transcribed sequences in the Down syndrome region-2.
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| Vidal-Taboada JM, et al.
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| Biochem Biophys Res Commun 243 : 572-578. 1998
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| 28 | ETS2
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| ETS2 function is required to maintain the transformed state of human prostate cancer cells.
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| Sementchenko VI, et al.
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| Oncogene 17 : 2883-2888. 1998
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| 29 | D21S155, ETS2, MX1
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| BAC and PAC contigs covering 3.5 Mb of the Down syndrome congenital heart disease region between D21S55 and MX1 on chromosome 1.
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| Hubert RS, et al.
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| Genomics 41 : 218-226. 1997
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| 30 | ERF, ETS2
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| Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF).
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| de Castro CM, Rabe SM, Langdon SD, Fleenor DE, Slentz-Kesler K, Ahmed MN, Qumsiyeh MB, Kaufman RE.
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| Genomics 42(2):227-35. 1997
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| 31 | ETS2
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| Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice.
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| Sumarsono SH, et al.
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| Nature 379 : 534-537. 1996
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| 32 | ETS2, SPI1
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| PU.1 but not ets-2 is essential for macrophage development from embryonic stem cells.
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| Henkel GW, McKercher SR, Yamamoto H, Anderson KL, Oshima RG, Maki RA.
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| Blood 88(8):2917-26 1996
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| 33 | ETS2, HMGN1, ITGB2, COL6A1
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| DNA polymorphisms in the 3' untranslated region of genes on human chromosome 21.
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| Avramopoulos D, et al.
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| Genomics 15 : 98-102. 1993
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| 34 | ETS2
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| New chromosome 21 DNA markers isolated by pulsed field gel electrophoresis from an ETS2-containing Down syndrome chromosomal region.
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| Yaspo ML, et al.
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| Hum Genet 90 : 427-434. 1992
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| 35 | ETS1, ETS2
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| The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation.
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| Wasylyk B, et al.
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| Nature 346 : 191-193. 1990
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| 36 | ETS1, ETS2, D1S100, D1S101
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| Detection of single-copy genes by nonisotopic in situ hybridization on human chromosomes.
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| Cherif D, et al.
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| Hum Genet 81 : 358-362. 1989
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| 37 | ETS2, ERG
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| The ETS genes on chromosome 21 are distal to the breakpoint of the acute myelogenous leukemia translocation (8;21).
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| Sacchi N, et al.
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| Genomics 3 : 110-116. 1988
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| 38 | ETS2, SST
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| Further evidence of homology between human chromosome 21 and the distal tip of mouse chromosome 16.
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| Ashley PL, et al.
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| (HGM9) Cytogenet Cell Genet 46 : 573. 1987
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| 39 | ETS2
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| Regional mapping of ETS2 on chromosome 21 in normal Alzheimer disease individual.
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| Blanquet V, et al.
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| (HGM9) Cytogenet Cell Genet 46 : 583. 1987
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| 40 | ETS1, ETS2
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| Hu-ets-1 and Hu-ets-2 genes are transposed in acute leukemias with (4;11) and (8;21) translocations.
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| Sacchi N, et al.
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| Science 231 : 379-381. 1986
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| 41 | ETS2
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| Hu-ets-2 is translocated to chromosome 8 in the t(8;21) in acute myelogenous leukemia.
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| Le Beau MM, et al.
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| Cancer Genet Cytogenet 23 : 269-274. 1986
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| 42 | ETS1, ETS2
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| The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21 : both loci are transcriptionally active.
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| Watson DK, McWilliams-Smith MJ, Nunn MF, Duesberg PH, O'Brien SJ, Papas TS.
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| Proc Natl Acad Sci U S A 82 : 7294-7298. 1985
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