| 1 | ERG, TMPRSS2
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| Retention of Interstitial Genes between TMPRSS2 and ERG Is Associated with Low-Risk Prostate Cancer.
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| Murphy SJ, Kosari F, Karnes RJ, Nasir A, Johnson SH, Gaitatzes AG, Smadbeck JB, Rangel LJ, Vasmatzis G, Cheville JC.
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| Cancer Res 77(22):6157-6167. doi: 10.1158/0008-5472.CAN-17-0529. Epub 2017 Nov 10.
2017
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| 2 | CNOT2, ERG, RBPMS
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| The transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression.
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| Rambout X, Detiffe C, Bruyr J, Mariavelle E, Cherkaoui M, Brohée S, Demoitié P, Lebrun M, Soin R, Lesage B, Guedri K, Beullens M, Bollen M, Farazi TA, Kettmann R, Struman I, Hill DE, Vidal M, Kruys V, Simonis N, Twizere JC, Dequiedt F.
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| Nat Struct Mol Biol 23(7):663-72. doi: 10.1038/nsmb.3243.
2016
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| 3 | AMLACR, ERG
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| High alpha-methylacyl-CoA racemase (AMACR) is associated with ERG expression and with adverse clinical outcome in patients with localized prostate cancer.
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| Box A, Alshalalfa M, Hegazy SA, Donnelly B, Bismar TA.
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| Tumour Biol 37(9):12287-12299. Epub 2016 Jun 7.
2016
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| 4 | ERG, TMPRSS2
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| Inflammation-Induced Oxidative Stress Mediates Gene Fusion Formation in Prostate Cancer.
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| Mani RS, Amin MA, Li X, Kalyana-Sundaram S, Veeneman BA, Wang L, Ghosh A, Aslam A, Ramanand SG, Rabquer BJ, Kimura W, Tran M, Cao X, Roychowdhury S, Dhanasekaran SM, Palanisamy N, Sadek HA, Kapur P, Koch AE, Chinnaiyan AM.
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| Cell Rep 17(10):2620-2631. doi: 10.1016/j.celrep.2016.11.019.
2016
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| 5 | ERG, SPOP
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| SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.
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| Gan W, Dai X, Lunardi A, Li Z, Inuzuka H, Liu P, Varmeh S, Zhang J, Cheng L, Sun Y, Asara JM, Beck AH, Huang J, Pandolfi PP, Wei W.
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| Mol Cell 59(6):917-30. doi: 10.1016/j.molcel.2015.07.026. Epub 2015 Sep 3.
2015
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| 6 | ERG, TMPRSS2
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| TMPRSS2:ERG gene fusion predicts subsequent detection of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia.
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| Park K, Dalton JT, Narayanan R, Barbieri CE, Hancock ML, Bostwick DG, Steiner MS, Rubin MA.
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| J Clin Oncol 32(3):206-11. doi: 10.1200/JCO.2013.49.8386. Epub 2013 Dec 2.
2014
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| 7 | ERG, LEF1
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| ERG is a critical regulator of Wnt/LEF1 signaling in prostate cancer.
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| Wu L, Zhao JC, Kim J, Jin HJ, Wang CY, Yu J.
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| Cancer Res 73(19):6068-79. doi: 10.1158/0008-5472.CAN-13-0882. Epub 2013 Aug 1.
2013
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| 8 | ERG
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| Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited.
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| Regan MC, Horanyi PS, Pryor EE Jr, Sarver JL, Cafiso DS, Bushweller JH.
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| Proc Natl Acad Sci U S A 110(33):13374-9. doi: 10.1073/pnas.1301726110. Epub 2013 Jul 29.
2013
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| 9 | AR, ERG, SOX9
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| ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer.
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| Cai C, Wang H, He HH, Chen S, He L, Ma F, Mucci L, Wang Q, Fiore C, Sowalsky AG, Loda M, Liu XS, Brown M, Balk SP, Yuan X.
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| J Clin Invest 123(3):1109-22. doi: 10.1172/JCI66666. Epub 2013 Feb 15.
2013
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| 10 | ERG, TDRD1
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| Identification of TDRD1 as a direct target gene of ERG in primary prostate cancer.
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| Boormans JL, Korsten H, Ziel-van der Made AJ, van Leenders GJ, de Vos CV, Jenster G, Trapman J.
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| Int J Cancer 133(2):335-45. doi: 10.1002/ijc.28025. Epub 2013 Feb 12.
2013
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| 11 | ERG
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| ERG transcriptional networks in primary acute leukemia cells implicate a role for ERG in deregulated kinase signaling.
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| Bock J, Mochmann LH, Schlee C, Farhadi-Sartangi N, Göllner S, Müller-Tidow C, Baldus CD.
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| PLoS One 8(1):e52872. doi: 10.1371/journal.pone.0052872. Epub 2013 Jan 3.
2013
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| 12 | ERG, SLC45A3
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| Loss of SLC45A3 protein (prostein) expression in prostate cancer is associated with SLC45A3-ERG gene rearrangement and an unfavorable clinical course.
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| Perner S, Rupp NJ, Braun M, Rubin MA, Moch H, Dietel M, Wernert N, Jung K, Stephan C, Kristiansen G.
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| Int J Cancer 132(4):807-12. doi: 10.1002/ijc.27733. Epub 2012 Aug 30.
2013
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| 13 | ERG, RELA
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| The transcription factor Erg controls endothelial cell quiescence by repressing activity of nuclear factor (NF)-κB p65.
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| Dryden NH, Sperone A, Martin-Almedina S, Hannah RL, Birdsey GM, Khan ST, Layhadi JA, Mason JC, Haskard DO, Göttgens B, Randi AM.
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| J Biol Chem 287(15):12331-42. doi: 10.1074/jbc.M112.346791. Epub 2012 Feb 15.
2012
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| 14 | CLDN5, ERG
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| ETS-related gene (ERG) controls endothelial cell permeability via transcriptional regulation of the claudin 5 (CLDN5) gene.
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| Yuan L, Le Bras A, Sacharidou A, Itagaki K, Zhan Y, Kondo M, Carman CV, Davis GE, Aird WC, Oettgen P.
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| J Biol Chem 287(9):6582-91. doi: 10.1074/jbc.M111.300236. Epub 2012 Jan 10.
2012
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| 15 | ERG, WNT11
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| Genome-wide screen reveals WNT11, a non-canonical WNT gene, as a direct target of ETS transcription factor ERG.
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| Mochmann LH, Bock J, Ortiz-Tánchez J, Schlee C, Bohne A, Neumann K, Hofmann WK, Thiel E, Baldus CD.
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| Oncogene 30(17):2044-56. Epub 2011 Jan 17.
2011
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| 16 | ERG
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| ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification.
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| Taoudi S, Bee T, Hilton A, Knezevic K, Scott J, Willson TA, Collin C, Thomas T, Voss AK, Kile BT, Alexander WS, Pimanda JE, Hilton DJ.
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| Genes Dev 25(3):251-62. Epub 2011 Jan 18.
2011
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| 17 | ERG
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| ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer.
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| Thoms JA, Birger Y, Foster S, Knezevic K, Kirschenbaum Y, Chandrakanthan V, Jonquieres G, Spensberger D, Wong JW, Oram SH, Kinston SJ, Groner Y, Lock R, MacKenzie KL, Göttgens B, Izraeli S, Pimanda JE.
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| Blood 117(26):7079-89. Epub 2011 May 2.
2011
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| 18 | ERG, TMPRSS2
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| TMPRSS2-ERG Gene Fusion and Clinicopathologic Characteristics of Korean Prostate Cancer Patients.
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| Lee K, Chae JY, Kwak C, Ku JH, Moon KC.
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| Urology rology. 2010 Aug 26. [Epub ahead of print]PMID: 20800881 2010
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| 19 | ERG, TMPRSS2
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| ERG rearrangement is present in a subset of transition zone prostatic tumors.
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| Falzarano SM, Navas M, Simmerman K, Klein EA, Rubin MA, Zhou M, Magi-Galluzzi C.
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| Mod Pathol od Pathol. 2010 Aug 6. [Epub ahead of print]PMID: 20693982 2010
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| 20 | AKT, ERG, PTEN, TMPRSS2
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| Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis.
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| King JC, Xu J, Wongvipat J, Hieronymus H, Carver BS, Leung DH, Taylor BS, Sander C, Cardiff RD, Couto SS, Gerald WL, Sawyers CL.
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| Nat Genet 41(5):524-6. Epub 2009 Apr 26.
2009
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| 21 | AKT, ERG, PTEN, TMPRSS2, TMPRSS6
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| Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.
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| Carver BS, Tran J, Gopalan A, Chen Z, Shaikh S, Carracedo A, Alimonti A, Nardella C, Varmeh S, Scardino PT, Cordon-Cardo C, Gerald W, Pandolfi PP.
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| Nat Genet 41(5):619-24. Epub 2009 Apr 26. 2009
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| 22 | ERG
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| Distinct genomic aberrations associated with ERG rearranged prostate cancer.
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| Demichelis F, Setlur SR, Beroukhim R, Perner S, Korbel JO, Lafargue CJ, Pflueger D, Pina C, Hofer MD, Sboner A, Svensson MA, Rickman DS, Urban A, Snyder M, Meyerson M, Lee C, Gerstein MB, Kuefer R, Rubin MA.
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| Genes Chromosomes Cancer 48(4):366-80.
2009
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| 23 | ERG, TMPRSS2
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| Genome-wide linkage analysis of TMPRSS2-ERG fusion in familial prostate cancer.
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| Hofer MD, Kuefer R, Maier C, Herkommer K, Perner S, Demichelis F, Paiss T, Vogel W, Rubin MA, Hoegel J.
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| Cancer Res 69(2):640-6.
2009
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| 24 | ERG, NDRG1
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| N-myc downstream regulated gene 1 (NDRG1) is fused to ERG in prostate cancer.
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| Pflueger D, Rickman DS, Sboner A, Perner S, LaFargue CJ, Svensson MA, Moss BJ, Kitabayashi N, Pan Y, de la Taille A, Kuefer R, Tewari AK, Demichelis F, Chee MS, Gerstein MB, Rubin MA.
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| Neoplasia 11(8):804-11.
2009
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| 25 | ERG
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| Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin.
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| Birdsey GM, Dryden NH, Amsellem V, Gebhardt F, Sahnan K, Haskard DO, Dejana E, Mason JC, Randi AM.
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| Blood 111(7):3498-506. Epub 2008 Jan 14.
2008
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| 26 | ERG, TMPRSS2
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| Detection of the TMPRSS2-ETS fusion gene in prostate carcinomas: retrospective analysis of 55 formalin-fixed and paraffin-embedded samples with clinical data.
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| Rouzier C, Haudebourg J, Carpentier X, Valério L, Amiel J, Michiels JF, Pedeutour F.
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| Cancer Genet Cytogenet 183(1):21-7.PMID: 18474293 2008
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| 27 | ERG
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| TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation.
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| Sun C, Dobi A, Mohamed A, Li H, Thangapazham RL, Furusato B, Shaheduzzaman S, Tan SH, Vaidyanathan G, Whitman E, Hawksworth DJ, Chen Y, Nau M, Patel V, Vahey M, Gutkind JS, Sreenath T, Petrovics G, Sesterhenn IA, McLeod DG, Srivastava S.
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| Oncogene 27(40):5348-53. Epub 2008 Jun 9.
2008
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| 28 | TMPRSS2, ERG
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| Multiple genomic alterations on 21q22 predict various TMPRSS2/ERG fusion transcripts in human prostate cancers.
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| Liu W, Ewing CM, Chang BL, Li T, Sun J, Turner AR, Dimitrov L, Zhu Y, Sun J, Kim JW, Zheng SL, Isaacs WB, Xu J.
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| Genes Chromosomes Cancer 46(11):972-80. 2007
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| 29 | ERG, TMPRSS2
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| Diversity of TMPRSS2-ERG fusion transcripts in the human prostate.
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| Clark J, Merson S, Jhavar S, Flohr P, Edwards S, Foster CS, Eeles R, Martin FL, Phillips DH, Crundwell M, Christmas T, Thompson A, Fisher C, Kovacs G, Cooper CS.
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| Oncogene 26(18):2667-73. Epub 2006 Oct 16.
2007
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| 30 | ERG, TMPRSS2
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| TMPRSS2-ERG fusion heterogeneity in multifocal prostate cancer: clinical and biologic implications.
|
| Barry M, Perner S, Demichelis F, Rubin MA.
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| Urology 70(4):630-3.
2007
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| 31 | ELF4, ERG
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| ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22).
|
| Moore SD, Offor O, Ferry JA, Amrein PC, Morton CC, Dal Cin P.
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| Leuk Res 30(8):1037-42. Epub 2005 Nov 21. 2006
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| 32 | ERG, ETV1, TMPRSS2
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| Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.
|
| Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, Sun XW, Varambally S, Cao X, Tchinda J, Kuefer R, Lee C, Montie JE, Shah RB, Pienta KJ, Rubin MA, Chinnaiyan AM.
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| Science 310(5748):644-8. 2005
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| 33 | C21orf24, ERG, ETS2
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| Detailed mapping of the ERG-ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16.
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| Owczarek CM, Portbury KJ, Hardy MP, O'Leary DA, Kudoh J, Shibuya K, Shimizu N, Kola I, Hertzog PJ.
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| Gene 324:65-77. 2004
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| 34 | FUS, ERG
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| FUS/ERG gene fusions in Ewing's tumors.
|
| Shing DC, McMullan DJ, Roberts P, Smith K, Chin SF, Nicholson J, Tillman RM, Ramani P, Cullinane C, Coleman N.
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| Cancer Res 63(15):4568-76. 2003
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| 35 | ERG, SETDB1
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| Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor.
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| Yang L, Xia L, Wu DY, Wang H, Chansky HA, Schubach WH, Hickstein DD, Zhang Y.
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| Oncogene 21(1):148-52. 2002
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| 36 | ID2, EWSR1, FLI1, ERG
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| The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors.
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| Nishimori H, Sasaki Y, Yoshida K, Irifune H, Zembutsu H, Tanaka T, Aoyama T, Hosaka T, Kawaguchi S, Wada T, Hata J, Toguchida J, Nakamura Y, Tokino T.
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| Oncogene 21(54):8302-9. 2002
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| 37 | ERG, EWSR1
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| Fine-mapping of cytogenetically undetectable EWS/ERG fusions on DNA fibers of Ewing tumors.
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| Hattinger CM, Rumpler S, Kovar H, Ambros PF.
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| Cytogenet Cell Genet 93(1-2):29-35. 2001
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| 38 | ERG
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| Selective expression of erg isoforms in human endothelial cells.
|
| Hewett PW, Nishi K, Daft EL, Clifford Murray J.
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| Int J Biochem Cell Biol 33(4):347-55.
2001
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| 39 | CHAF1B, CBR1, ERG, DSCR4, DSCR8
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| Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome.
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| Dahmane N, Ghezala GA, Gosset P, Chamoun Z, Dufresne-Zacharia MC, Lopes C, Rabatel N, Gassanova-Maugenre S, Chettouh Z, Abramowski V, Fayet E, Yaspo ML, Korn B, Blouin JL, Lehrach H, Poutska A, Antonarakis SE, Sinet PM, Creau N, Delabar JM.
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| Genomics 48(1):12-23. 1998
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| 40 | ERG, EWSR1, EWSR1
|
| EWS-ERG fusion transcript produced by chromosomal insertion in a Ewing sarcoma.
|
| Kaneko Y, et al.
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| Genes Chromosomes Cancer 18 : 228-231. 1997
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| 41 | ERG, FUS, AMLT1
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| Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript.
|
| Kong XT, Ida K, Ichikawa H, Shimizu K, Ohki M, Maseki N, Kaneko Y, Sako M, Kobayashi Y, Tojou A, Miura I, Kakuda H, Funabiki T, Horibe K, Hamaguchi H, Akiyama Y, Bessho F, Yanagisawa M, Hayashi Y.
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| Blood 90(3):1192-9. 1997
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| 42 | DDIT3, ERG, EWSR1, FUS
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| Characteristic sequence motifs at the breakpoints of the hybrid genes FUS/CHOP, EWS/CHOP and FUS/ERG in myxoid liposarcoma and acute myeloid leukemia.
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| Panagopoulos I, Lassen C, Isaksson M, Mitelman F, Mandahl N, Aman P.
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| Oncogene 15(11):1357-62. 1997
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| 43 | RCAN1, ERG, SIM2
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| A 1.6-Mb P1-based physical map of the Down syndrome region on chromosome21.
|
| Ohira M, et al.
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| Genomics 33 : 65-74. 1996
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| 44 | DDIT3, ERG, FUS
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| Two distinct FUS breakpoint clusters in myxoid liposarcoma and acute myeloid leukemia with the translocations t(12;16) and t(16;21).
|
| Panagopoulos I, et al.
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| oncogene 11 : 1133-1137 1995
|
| 45 | ERG, EWSR1, EWSR1, FLI1
|
| A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG.
|
| Sorensen PHB, et al.
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| Nat Genet 6 : 146-151. 1994
|
| 46 | FUS, ERG
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| TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domain.
|
| Prasad DDK, et al.
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| Oncogene 9 : 3717-3729. 1994
|
| 47 | FUS, ERG
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| Fusion of the FUS gene with ERG in acute myeloid leukemia with t(16;21)(p11;q22).
|
| Panagopoulos I, et al.
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| Genes Chromosomes Cancer 11 : 256-262. 1994
|
| 48 | ERG
|
| An ets-related gene, ERG, is rearranged in human myeloid leukemia with t(16;21) chromosomal translocation.
|
| Shimizu K, et al.
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| Proc Natl Acad Sci U S A 90 : 10280-10284. 1993
|
| 49 | ERG
|
| Chromosomal localization of the erg cellular proto-oncogene.
|
| Modi WS, et al.
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| (HGM10) Cytogenet Cell Genet 51 : 1046. 1989
|
| 50 | ERG
|
| The human erg gene maps to chromosome 21, band q22 : relationship to the 8;21 translocation of acute myelogenous leukemia.
|
| Rao VN, et al.
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| Oncogene 3 : 497-500. 1988
|
| 51 | ETS2, ERG
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| The ETS genes on chromosome 21 are distal to the breakpoint of the acute myelogenous leukemia translocation (8;21).
|
| Sacchi N, et al.
|
| Genomics 3 : 110-116. 1988
|
| 52 | ERG
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| Erg, a human ets-related gene on chromosome 21: Alternative splicing polyadenylation and translation.
|
| Rao VN, et al.
|
| Science 237 : 635-639. 1987
|