Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ELMO2 contributors: mct - updated : 08-02-2014
HGNC name engulfment and cell motility 2
HGNC id 17233
Corresponding disease
VMOS vascular malformation intraosseous, primary
Location 20q13.12      Physical location : 44.994.689 - 45.035.271
Synonym name
  • engulfment and cell motility 2 (ced-12 homolog, C. elegans)
  • PH domain protein CED12A
  • ced-12 homolog 2
  • Synonym symbol(s) KIAA1834, CED12, CED-12, ELMO-2, FLJ11656
    DNA
    TYPE functioning gene
    STRUCTURE 40.58 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PTE1 20q12-q13.1 peroxisomal acyl-CoA thioesterase ZSWIM3 20q13.12 zinc finger, SWIM domain containing 3 ZSWIM1 20q13.12 zinc finger, SWIM domain containing 1 C20orf165 20q13.12 chromosome 20 open reading frame 165 C20orf163 20q13.12 chromosome 20 open reading frame 163 PPGB 20q13.1 protective protein for beta-galactosidase (galactosialidosis) PLTP 20q12 phospholipid transfer protein C20orf67 20q13.12 chromosome 20 open reading frame 67 ZNF335 20q11.21-q13.12 zinc finger protein 335 FTLP 20q13.12 ferritin, light polypeptide pseudogene MMP9 20q11.2 matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) LOC128499 20q13.12 hypothetical LOC128499 SLC12A5 20q12-q13.1 solute carrier family 12, (potassium-chloride transporter) member 5 NCOA5 20q12-q13.2 nuclear receptor coactivator 5 RPL13P2 20q13.12 ribosomal protein L13 pseudogene 2 TNFRSF5 20q12-q13.2 tumor necrosis factor receptor superfamily, member 5 CDH22 20q12-q13.1 cadherin-like 22 SLC35C2 20q13.12 solute carrier family 35, member C2 ELMO2 20q13 engulfment and cell motility 2 (ced-12 homolog, C. elegans) DKFZp547G0215 20q13.12 hypothetical protein DKFZp547G0215 MKRNP3 20q21.1 makorin, ring finger protein, pseudogene 3 LOC343593 20q13.12 similar to BC331191_1 ZNF334 20q13.12 zinc finger protein 334 SLC13A3 20q12-q13.1 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 C20orf64 20q13 chromosome 20 open reading frame 64 SLC2A10 20q13.1 solute carrier family 2 (facilitated glucose transporter), member 10
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 3683 79 720 - 2001 11595183
    21 - 3596 79 720 - 2001 11595183
    3'utr short
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to C.elegans
    ortholog to Drosophila Ced12
    intraspecies paralog to ELMO1
    paralog to ELMO3
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • upstream regulator of RAC1 required for engulfment of dying cells and for cell migration
  • may function in phagocytosis of apoptotic cells and in cell migration
  • role of ILK and ELMO2 in the integration of adhesion and migration pathways
  • role for ELMO1, ELMO2, ELMO3 in protrusion stability by acting at the interface between the actin cytoskeleton and the microtubule network
  • exogenous expression of ELMO2 or RHOG stabilizes microtubules, but only if ILK is also present
  • recruited to the plasma membrane and involved in the signaling cascade that controls cytoskeleton dynamics and cell migration
  • necessity of ELMO2 for maintaining vascular integrity, specifically in intramembranous bones
  • CELLULAR PROCESS cell life, cell death/apoptosis
    cell organization/biogenesis
    cell communication
    PHYSIOLOGICAL PROCESS
    text cytoskeletal rearrangements during phagocytosis and cell motility in the late steps of the apoptotic process (complementation group 2 in C elegans)
    PATHWAY
    metabolism
    signaling signal transduction
    a component probably part of a complex with DOCK1 and CRK isoform CRK-II
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the dedicator of cyto-kinesis 1 protein
  • interacts with the SH3-domain of DOCK1 via its SH3- binding site
  • interaction with ILK (interaction with ELMO2 and RHOG is essential for the ability of ILK to induce front-rear cell polarity)
  • EGF-induction of front-rear polarity and migration in keratinocytes is mediated by integrin-linked kinase and ELMO2
  • ILK-binding protein in epidermal keratinocytes
  • role for ELMO2 in the recruitment of MACF1 to the membrane to promote microtubule capture and stability
  • MACF1 interacts with ELMO2 and ELMO3
  • ELMO2 scaffolds to be direct substrates and binding partners of AXL
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) VMOS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS