basic FUNCTION
| upstream regulator of RAC1 required for engulfment of dying cells and for cell migration |
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may function in phagocytosis of apoptotic cells and in cell migration |
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role of ILK and ELMO2 in the integration of adhesion and migration pathways |
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role for ELMO1, ELMO2, ELMO3 in protrusion stability by acting at the interface between the actin cytoskeleton and the microtubule network |
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exogenous expression of ELMO2 or RHOG stabilizes microtubules, but only if ILK is also present |
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recruited to the plasma membrane and involved in the signaling cascade that controls cytoskeleton dynamics and cell migration |
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necessity of ELMO2 for maintaining vascular integrity, specifically in intramembranous bones |