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FLASH GENE
Symbol ELMO2 contributors: mct - updated : 08-02-2014
HGNC name engulfment and cell motility 2
HGNC id 17233
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 3683 79 720 - 2001 11595183
21 - 3596 79 720 - 2001 11595183
3'utr short
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Reproductivemale systemtestis  highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to C.elegans
ortholog to Drosophila Ced12
intraspecies paralog to ELMO1
paralog to ELMO3
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,cytosolic
intracellular,cytoplasm,cytoskeleton
basic FUNCTION
  • upstream regulator of RAC1 required for engulfment of dying cells and for cell migration
  • may function in phagocytosis of apoptotic cells and in cell migration
  • role of ILK and ELMO2 in the integration of adhesion and migration pathways
  • role for ELMO1, ELMO2, ELMO3 in protrusion stability by acting at the interface between the actin cytoskeleton and the microtubule network
  • exogenous expression of ELMO2 or RHOG stabilizes microtubules, but only if ILK is also present
  • recruited to the plasma membrane and involved in the signaling cascade that controls cytoskeleton dynamics and cell migration
  • necessity of ELMO2 for maintaining vascular integrity, specifically in intramembranous bones
  • CELLULAR PROCESS cell life, cell death/apoptosis
    cell organization/biogenesis
    cell communication
    PHYSIOLOGICAL PROCESS
    text cytoskeletal rearrangements during phagocytosis and cell motility in the late steps of the apoptotic process (complementation group 2 in C elegans)
    PATHWAY
    metabolism
    signaling signal transduction
    a component probably part of a complex with DOCK1 and CRK isoform CRK-II
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the dedicator of cyto-kinesis 1 protein
  • interacts with the SH3-domain of DOCK1 via its SH3- binding site
  • interaction with ILK (interaction with ELMO2 and RHOG is essential for the ability of ILK to induce front-rear cell polarity)
  • EGF-induction of front-rear polarity and migration in keratinocytes is mediated by integrin-linked kinase and ELMO2
  • ILK-binding protein in epidermal keratinocytes
  • role for ELMO2 in the recruitment of MACF1 to the membrane to promote microtubule capture and stability
  • MACF1 interacts with ELMO2 and ELMO3
  • ELMO2 scaffolds to be direct substrates and binding partners of AXL
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) VMOS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS