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FLASH GENE

Symbol

EIF3I

contributors: - updated : 17-08-2007

HGNC name	eukaryotic translation initiation factor 3, subunit I
HGNC id	3272

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p34.1      Physical location : 32.687.970 - 32.697.204
Synonym name	transforming growth factor beta receptor interacting protein 1
	eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa
Synonym symbol(s)	TRIP1, TIF3, TRIP-1, eIF3-p36, eIF3-beta, EIF3S2

DNA

TYPE	functioning gene
STRUCTURE	9.00 kb     11 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Reproductive female system uterus cervix   highly Urinary bladder       highly

cell lineage
cell lines	Hela cells
fluid/secretion

at STAGE

physiological period

fetal

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	five WD-40 repeats
	a putative ATP/GTP binding site

HOMOLOGY

Homologene

FAMILY

eukaryotic translation initiation factor family

CATEGORY

RNA associated , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,ribosome

basic FUNCTION	stabilizing initiator Met tRNA (TRIMs) binding to 40S subunits
	promoting the association of Met-tRNA and mRNA
	cadmium-responsive proto-oncogene

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

components of the EIF3 multiprotein complex, 600kDa

INTERACTION

DNA

RNA	binding to the 40S ribosome

small molecule

protein

binding to TGFBR

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS