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FLASH GENE
Symbol EIF3I contributors: - updated : 17-08-2007
HGNC name eukaryotic translation initiation factor 3, subunit I
HGNC id 3272
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Reproductivefemale systemuteruscervix highly
Urinarybladder   highly
cell lineage
cell lines Hela cells
fluid/secretion
at STAGE
physiological period fetal
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five WD-40 repeats
  • a putative ATP/GTP binding site
    • HOMOLOGY
    Homologene
    FAMILY eukaryotic translation initiation factor family
    CATEGORY RNA associated , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • stabilizing initiator Met tRNA (TRIMs) binding to 40S subunits
  • promoting the association of Met-tRNA and mRNA
  • cadmium-responsive proto-oncogene
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • components of the EIF3 multiprotein complex, 600kDa
    • INTERACTION
    DNA
    RNA binding to the 40S ribosome
    small molecule
    protein
  • binding to TGFBR
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS