| 1 | EGR1, IRX2
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| IRX2 regulates angiotensin II-induced cardiac fibrosis by transcriptionally activating EGR1 in male mice.
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| Ma ZG, Yuan YP, Fan D, Zhang X, Teng T, Song P, Kong CY, Hu C, Wei WY, Tang QZ.
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| Nat Commun. Aug 16;14(1):4967. doi: 10.1038/s41467-023-40639-6 2023
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| 2 | DUSP1, EGR1
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| DUSP1/MKP-1 regulates proliferation and apoptosis in keratinocytes through the ERK/Elk-1/Egr-1 signaling pathway.
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| Yang J, Sun L, Han J, Zheng W, Peng W.
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| Life Sci. Apr 15;223:47-53. doi: 10.1016/j.lfs.2019.03.018. Epub 2019 Mar 9. 2019
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| 3 | APP, BACE1, EGR1
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| Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of β-Secretase 1 (BACE-1) in the Brain.
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| Qin X, Wang Y, Paudel HK.
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| J Biol Chem 291(42):22276-22287. Epub 2016 Aug 30.
2016
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| 4 | EGR1, TOE1
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| TOE1 is an inhibitor of HIV-1 replication with cell-penetrating capability.
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| Sperandio S, Barat C, Cabrita MA, Gargaun A, Berezovski MV, Tremblay MJ, de Belle I.
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| Proc Natl Acad Sci U S A 112(26):E3392-401. doi: 10.1073/pnas.1500857112. Epub 2015 Jun 8.
2015
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| 5 | EGR1, KRT18
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| EGR1 decreases the malignancy of human non-small cell lung carcinoma by regulating KRT18 expression.
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| Zhang H, Chen X, Wang J, Guang W, Han W, Zhang H, Tan X, Gu Y.
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| Sci Rep 4:5416. doi: 10.1038/srep05416.
2014
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| 6 | APLN, EGR1, SPP1
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| Apelin-13-induced proliferation and migration induced of rat vascular smooth muscle cells is mediated by the upregulation of Egr-1.
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| Liu QF, Yu HW, You L, Liu MX, Li KY, Tao GZ.
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| Biochem Biophys Res Commun 439(2):235-40. doi: 10.1016/j.bbrc.2013.08.051. Epub 2013 Aug 22.
2013
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| 7 | EGR1, EGR2
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| Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling.
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| Seiler MP, Mathew R, Liszewski MK, Spooner C, Barr K, Meng F, Singh H, Bendelac A.
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| Nat Immunol at Immunol. 2012 Feb 5. doi: 10.1038/ni.2230. [Epub ahead of print]
2012
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| 8 | EGR1, EGR2
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| Early growth response genes signaling supports strong paracrine capability of mesenchymal stem cells.
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| Tamama K, Barbeau DJ.
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| Stem Cells Int 2012:428403. doi: 10.1155/2012/428403. Epub 2012 Dec 6.
2012
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| 9 | EGR1, MAML1
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| MAML1 acts cooperatively with EGR1 to activate EGR1-regulated promoters: implications for nephrogenesis and the development of renal cancer.
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| Hansson ML, Behmer S, Ceder R, Mohammadi S, Preta G, Grafström RC, Fadeel B, Wallberg AE.
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| PLoS One 7(9):e46001. doi: 10.1371/journal.pone.0046001. Epub 2012 Sep 27.
2012
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| 10 | ARF1, EGR1
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| Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism.
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| Boone DN, Qi Y, Li Z, Hann SR.
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| Proc Natl Acad Sci U S A 108(2):632-7. Epub 2010 Dec 27.
2011
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| 11 | EGR1
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| Egr-1 transactivates Bim gene expression to promote neuronal apoptosis.
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| Xie B, Wang C, Zheng Z, Song B, Ma C, Thiel G, Li M.
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| J Neurosci. 31(13):5032-44. 2011
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| 12 | EGR1, GGPS1
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| An early response transcription factor, Egr-1, enhances insulin resistance in type 2 diabetes with chronic hyperinsulinism.
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| Shen N, Yu X, Pan FY, Gao X, Xue B, Li CJ.
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| J Biol Chem 286(16):14508-15. Epub 2011 Feb 14.
2011
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| 13 | EGR1
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| Early growth response 1 (Egr1) regulates cholesterol biosynthetic gene expression.
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| Gokey NG, Lopez-Anido C, Gillian-Daniel AL, Svaren J.
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| J Biol Chem 286(34):29501-10. Epub 2011 Jun 28.
2011
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| 14 | EGR1, MAPT
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| Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain.
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| Lu Y, Li T, Qureshi HY, Han D, Paudel HK.
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| J Biol Chem 286(23):20569-81. Epub 2011 Apr 13. 2011
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| 15 | EGR1
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| Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine.
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| Chen J, Liu MY, Parish CR, Chong BH, Khachigian L.
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| Int J Biochem Cell Biol 43(6):905-12. Epub 2011 Mar 17.
2011
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| 16 | EGR1, EGR2
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| EGR1 and EGR2 involvement in vertebrate tendon differentiation.
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| Lejard V, Blais F, Guerquin MJ, Bonnet A, Bonnin MA, Havis E, Malbouyres M, Bidaud CB, Maro G, Gilardi-Hebenstreit P, Rossert J, Ruggiero F, Duprez D.
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| J Biol Chem 286(7):5855-67. doi: 10.1074/jbc.M110.153106. Epub 2010 Dec 20.
2011
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| 17 | EGR1, IPO7
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| Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine.
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| Chen J, Liu MY, Parish CR, Chong BH, Khachigian L.
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| Int J Biochem Cell Biol 43(6):905-12. doi: 10.1016/j.biocel.2011.03.004. Epub 2011 Mar 17. 2011
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| 18 | CCK, EGR1, LEP
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| EGR1 Is a target for cooperative interactions between cholecystokinin and leptin, and inhibition by ghrelin, in vagal afferent neurons.
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| de Lartigue G, Lur G, Dimaline R, Varro A, Raybould H, Dockray GJ.
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| Endocrinology 151(8):3589-99. Epub 2010 Jun 9.PMID: 20534729 2010
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| 19 | EGR1, MMP9
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| EGR-1 activation by EGF inhibits MMP-9 expression and lymphoma growth.
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| Bouchard F, Bélanger SD, Biron-Pain K, St-Pierre Y.
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| Blood 116(5):759-66. Epub 2010 May 14.PMID: 20472833 2010
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| 20 | EGR1
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| Mature human neutrophils constitutively express the transcription factor EGR-1.
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| Cullen EM, Brazil JC, O'Connor CM.
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| Mol Immunol 47(9):1701-9. Epub 2010 Apr 2.PMID: 20363028 2010
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| 21 | EGR1, MMP9
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| Transcription factor Egr-1 is essential for maximal matrix metalloproteinase-9 transcription by tumor necrosis factor alpha.
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| Shin SY, Kim JH, Baker A, Lim Y, Lee YH.
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| Mol Cancer Res 8(4):507-19. Epub 2010 Mar 23.PMID: 20332214 2010
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| 22 | EGR1, PTEN
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| EGR1 reactivation by histone deacetylase inhibitors promotes synovial sarcoma cell death through the PTEN tumor suppressor.
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| Su L, Cheng H, Sampaio AV, Nielsen TO, Underhill TM.
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| Oncogene 29(30):4352-61. Epub 2010 May 31.PMID: 20514024 2010
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| 23 | EGR1
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| Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b.
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| Hu CT, Chang TY, Cheng CC, Liu CS, Wu JR, Li MC, Wu WS.
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| FEBS J. 277(5):1202-18. 2010
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| 24 | EGR1
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| T-box 2 represses NDRG1 through an EGR1-dependent mechanism to drive the proliferation of breast cancer cells.
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| Redmond KL, Crawford NT, Farmer H, D'Costa ZC, O'Brien GJ, Buckley NE, Kennedy RD, Johnston PG, Harkin DP, Mullan PB.
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| Oncogene. 29(22):3252-62 2010
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| 25 | EGR1, PGF
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| Placenta growth factor-induced early growth response 1 (Egr-1) regulates hypoxia-inducible factor-1alpha (HIF-1alpha) in endothelial cells.
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| Patel N, Kalra VK.
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| J Biol Chem 285(27):20570-9. Epub 2010 May 6.
2010
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| 26 | EGR1, EGR2, EGR3
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| EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin.
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| Kumbrink J, Kirsch KH, Johnson JP.
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| J Cell Biochem 111(1):207-17. doi: 10.1002/jcb.22690.
2010
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| 27 | EGR1, SOX18
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| Early growth response protein 1 acts as an activator of SOX18 promoter.
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| Petrovic I, Kovacevic-Grujicic N, Stevanovic M.
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| Exp Mol Med 42(2):132-42. doi: 10.3858/emm.2010.42.2.015.
2010
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| 28 | EGR1, EGR2
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| The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation.
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| Boyle KB, Hadaschik D, Virtue S, Cawthorn WP, Ridley SH, O'Rahilly S, Siddle K.
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| Cell Death Differ 16(5):782-9. Epub 2009 Feb 20.
2009
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| 29 | EGR1
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| Early growth response 1 (EGR1): a gene with as many names as biological functions.
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| DeLigio JT, Zorio DA.
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| Cancer Biol Ther 8(20):1889-92. Epub 2009 Oct 14.PMID: 20009530 2009
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| 30 | ATF5, EGR1
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| Identification of a novel DNA binding site and a transcriptional target for activating transcription factor 5 in c6 glioma and mcf-7 breast cancer cells.
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| Li G, Li W, Angelastro JM, Greene LA, Liu DX.
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| Mol Cancer Res 7(6):933-43. doi: 10.1158/1541-7786.MCR-08-0365. Epub 2009 Jun 16.
2009
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| 31 | EGR1, EGR2, EGR3
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| Epidermal-growth-factor-induced proliferation of astrocytes requires Egr transcription factors.
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| Mayer SI, Rössler OG, Endo T, Charnay P, Thiel G.
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| J Cell Sci 122(Pt 18):3340-50. doi: 10.1242/jcs.048272. Epub 2009 Aug 25.
2009
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| 32 | EGR1, UBE2S, VHL
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| Egr-1 and serum response factor are involved in growth factors- and serum-mediated induction of E2-EPF UCP expression that regulates the VHL-HIF pathway.
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| Lim JH, Jung CR, Lee CH, Im DS.
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| J Cell Biochem 105(4):1117-27.PMID: 18780286 2008
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| 33 | EGR1
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| The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells.
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| Min IM, Pietramaggiori G, Kim FS, Passegué E, Stevenson KE, Wagers AJ.
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| Cell Stem Cell 2(4):380-91.PMID: 18397757 2008
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| 34 | EGR1, G3BP1
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| Erythropoietin receptor-mediated Egr-1 activation: structural requirements and functional implications.
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| Schulze C, Büchse T, Mikkat S, Bittorf T.
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| Cell Signal 20(10):1848-54. Epub 2008 Jun 27.
2008
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| 35 | FGF23, EGR1, NAB2
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| FGF23 induces expression of two isoforms of NAB2, which are corepressors of Egr-1.
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| Fukuda T, Kanomata K, Nojima J, Urakawa I, Suzawa T, Imada M, Kukita A, Kamijo R, Yamashita T, Katagiri T.
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| Biochem Biophys Res Commun 353(1):147-51. Epub 2006 Dec 11. 2007
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| 36 | EGR1, EGR3
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| Egr3, a synaptic activity regulated transcription factor that is essential for learning and memory.
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| Li L, Yun SH, Keblesh J, Trommer BL, Xiong H, Radulovic J, Tourtellotte WG.
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| Mol Cell Neurosci 35(1):76-88. Epub 2007 Feb 12.
2007
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| 37 | EGR1
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| Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders.
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| Joslin JM, Fernald AA, Tennant TR, Davis EM, Kogan SC, Anastasi J, Crispino JD, Le Beau MM.
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| Blood 110(2):719-26. Epub 2007 Apr 9.
2007
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| 38 | EGR1
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| Relative axial myopia in Egr-1 (ZENK) knockout mice.
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| Schippert R, Burkhardt E, Feldkaemper M, Schaeffel F.
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| Invest Ophthalmol Vis Sci. 48(1):11-7. 2007
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| 39 | TOPBP1, EGR1
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| The transcription factor Egr-1 is a regulator of the human TopBP1 gene.
|
| Usskilat C, Skerka C, Saluz HP, Hanel F.
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| Gene 380(2):144-50. Epub 2006 Jun 8. 2006
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| 40 | EGR1, GNAQ
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| Early growth response transcription factor EGR-1 regulates Galphaq gene in megakaryocytic cells.
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| Jalagadugula G, Dhanasekaran DN, Kim S, Kunapuli SP, Rao AK.
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| J Thromb Haemost 4(12):2678-86. Epub 2006 Sep 22. 2006
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| 41 | COL1A2, EGR1
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| The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression.
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| Chen SJ, Ning H, Ishida W, Sodin-Semrl S, Takagawa S, Mori Y, Varga J.
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| J Biol Chem 281(30):21183-97. Epub 2006 May 15. 2006
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| 42 | NAB1, EGR1
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| The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy.
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| Buitrago M, Lorenz K, Maass AH, Oberdorf-Maass S, Keller U, Schmitteckert EM, Ivashchenko Y, Lohse MJ, Engelhardt S.
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| Nat Med 11(8):837-844. Epub 2005 Jul 17. 2005
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| 43 | FN1, POU5F1, MMP7, EGR1, AFP, IRX1, NR6A1
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| Gene expression profiling differentiates germ cell tumors from other cancers and defines subtype-specific signatures.
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| Juric D, Sale S, Hromas RA, Yu R, Wang Y, Duran GE, Tibshirani R, Einhorn LH, Sikic BI.
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| Proc Natl Acad Sci U S A 102(49):17763-8. Epub 2005 Nov 23. 2005
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| 44 | ATF3, EGR1
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| Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene.
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| Bottone FG Jr, Moon Y, Alston-Mills B, Eling TE.
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| J Pharmacol Exp Ther 315(2):668-77. Epub 2005 Aug 3. 2005
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| 45 | EGR1
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| Delayed hepatocellular mitotic progression and impaired liver regeneration in early growth response-1-deficient mice.
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| Liao Y, Shikapwashya ON, Shteyer E, Dieckgraefe BK, Hruz PW, Rudnick DA.
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| J Biol Chem. 279(41):43107-16. 2004
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| 46 | TNFSF10, CCL25, IFI30, EGR1
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| Egr-1 target genes in human endothelial cells identified by microarray analysis.
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| Fu M, Zhu X, Zhang J, Liang J, Lin Y, Zhao L, Ehrengruber MU, Chen YE.
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| Gene 315:33-41. 2003
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| 47 | EGR1, F3, CD40LG
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| Induction of tissue factor expression in human endothelial cells by CD40 ligand is mediated via activator protein 1, nuclear factor kappa B, and Egr-1.
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| Bavendiek U, Libby P, Kilbride M, Reynolds R, Mackman N, Schonbeck U.
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| J Biol Chem 277(28):25032-9. 2002
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| 48 | EGR1
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| Thymocyte development in early growth response gene 1-deficient mice.
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| Bettini M, Xi H, Milbrandt J, Kersh GJ.
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| J Immunol 169(4):1713-20. 2002
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| 49 | EGR1, MAOB
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| Activation of human monoamine oxidase B gene expression by a protein kinase C MAPK signal transduction pathway involves c-Jun and Egr-1.
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| Wong WK, Ou XM, Chen K, Shih JC.
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| J Biol Chem 277(25):22222-30. 2002
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| 50 | EGR1, DIDAN
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| Early growth response factor-1 is a critical transcriptional mediator of peroxisome proliferator-activated receptor-gamma 1 gene expression in human aortic smooth muscle cells.
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| Fu M, Zhang J, Lin Y, Zhu X, Ehrengruber MU, Chen YE.
|
| J Biol Chem 277(30):26808-14. 2002
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| 51 | EGR1
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| EGR1 target genes in prostate carcinoma cells identified by microarray analysis.
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| Svaren J, Ehrig T, Abdulkadir SA, Ehrengruber MU, Watson MA, Milbrandt J.
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| J Biol Chem 275(49):38524-31. 2000
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| 52 | ADRA2A, ADRB1, AGTR1, CAFG, CD36, CETP, CSF1, CSF2, CYP11B2, ECE1, EDN1, EDNRA, EDNRB, EGR1, F2R, FGA, FGB, FHBL1, HGF, ICAM1, IGF1, IL1A, IL6, LPA, MGP, MSR1, MTTP, NOS2, NOS3, PDGFA, PDGFRA, SELP, TGFB1, TNF, VCAM1, VDR
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| Sequence diversity in 36 candidate genes for cardiovascular disorders.
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| Cambien F, Poirier O, Nicaud V, Herrmann SM, Mallet C, Ricard S, Behague I, Hallet V, Blanc H, Loukaci V, Thillet J, Evans A, Ruidavets JB, Arveiler D, Luc G, Tiret L.
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| Am J Hum Genet 65(1):183-91. 1999
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| 53 | SH3TC2, EGR1
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| Genetic, cytogenetic and physical refinement of the autosomal recessive CMT linked to 5q31-q33: exclusion of candidate genes including EGR1.
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| No authors listed] Related Articles
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| Eur J Hum Genet 7(8):849-59 1999
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| 54 | CREBBP, EGR1
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| cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1).
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| Silverman ES, et al.
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| Biochem J 336 : 183-189. 1998
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| 55 | EGR1
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| Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1).
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| Lee SL, Sadovsky Y, Swirnoff AH, Polish JA, Goda P, Gavrilina G, Milbrandt J.
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| Science. 273(5279):1219-21. 1996
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| 56 | EGR1, IL9, CSF2, TSG5D
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| Physical mapping of the minimal region of loss in 5q- chromosome. (chromosome 5/deletion/leukemia).
|
| Fairman J, et al.
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| Proc Natl Acad Sci U S A 92 : 7406-7410. 1995
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| 57 | EGR1
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| Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals.
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| Cao X, et al.
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| Mol Cell Biol 10 : 1931-1939. 1990
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| 58 | EGR1
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| Structure, chromosome mapping and regulation of the mouse zinc finger gene Krox-24, evidence for a common regulatory pathway for immediate-early serum response genes.
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| Janssen-Timmen U, Lemaire P, Mattei MG, Revelant O, Charnay P.
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| Gene 80 : 325-336. 1989
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| 59 | EGR1
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| A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization.
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| Sukhatme VP, et al.
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| Cell 53 : 37-43. 1988
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