Citations for
1APP, BACE1, EGR1
Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of β-Secretase 1 (BACE-1) in the Brain.
Qin X, Wang Y, Paudel HK.
J Biol Chem 291(42):22276-22287. Epub 2016 Aug 30. 2016
2EGR1, TOE1
TOE1 is an inhibitor of HIV-1 replication with cell-penetrating capability.
Sperandio S, Barat C, Cabrita MA, Gargaun A, Berezovski MV, Tremblay MJ, de Belle I.
Proc Natl Acad Sci U S A 112(26):E3392-401. doi: 10.1073/pnas.1500857112. Epub 2015 Jun 8. 2015
3EGR1, KRT18
EGR1 decreases the malignancy of human non-small cell lung carcinoma by regulating KRT18 expression.
Zhang H, Chen X, Wang J, Guang W, Han W, Zhang H, Tan X, Gu Y.
Sci Rep 4:5416. doi: 10.1038/srep05416. 2014
4APLN, EGR1, SPP1
Apelin-13-induced proliferation and migration induced of rat vascular smooth muscle cells is mediated by the upregulation of Egr-1.
Liu QF, Yu HW, You L, Liu MX, Li KY, Tao GZ.
Biochem Biophys Res Commun 439(2):235-40. doi: 10.1016/j.bbrc.2013.08.051. Epub 2013 Aug 22. 2013
5EGR1, EGR2
Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling.
Seiler MP, Mathew R, Liszewski MK, Spooner C, Barr K, Meng F, Singh H, Bendelac A.
Nat Immunol at Immunol. 2012 Feb 5. doi: 10.1038/ni.2230. [Epub ahead of print] 2012
6EGR1, EGR2
Early growth response genes signaling supports strong paracrine capability of mesenchymal stem cells.
Tamama K, Barbeau DJ.
Stem Cells Int 2012:428403. doi: 10.1155/2012/428403. Epub 2012 Dec 6. 2012
7EGR1, MAML1
MAML1 acts cooperatively with EGR1 to activate EGR1-regulated promoters: implications for nephrogenesis and the development of renal cancer.
Hansson ML, Behmer S, Ceder R, Mohammadi S, Preta G, Grafström RC, Fadeel B, Wallberg AE.
PLoS One 7(9):e46001. doi: 10.1371/journal.pone.0046001. Epub 2012 Sep 27. 2012
8ARF1, EGR1
Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism.
Boone DN, Qi Y, Li Z, Hann SR.
Proc Natl Acad Sci U S A 108(2):632-7. Epub 2010 Dec 27. 2011
9EGR1
Egr-1 transactivates Bim gene expression to promote neuronal apoptosis.
Xie B, Wang C, Zheng Z, Song B, Ma C, Thiel G, Li M.
J Neurosci. 31(13):5032-44. 2011
10EGR1, GGPS1
An early response transcription factor, Egr-1, enhances insulin resistance in type 2 diabetes with chronic hyperinsulinism.
Shen N, Yu X, Pan FY, Gao X, Xue B, Li CJ.
J Biol Chem 286(16):14508-15. Epub 2011 Feb 14. 2011
11EGR1
Early growth response 1 (Egr1) regulates cholesterol biosynthetic gene expression.
Gokey NG, Lopez-Anido C, Gillian-Daniel AL, Svaren J.
J Biol Chem 286(34):29501-10. Epub 2011 Jun 28. 2011
12EGR1, MAPT
Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain.
Lu Y, Li T, Qureshi HY, Han D, Paudel HK.
J Biol Chem 286(23):20569-81. Epub 2011 Apr 13. 2011
13EGR1
Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine.
Chen J, Liu MY, Parish CR, Chong BH, Khachigian L.
Int J Biochem Cell Biol 43(6):905-12. Epub 2011 Mar 17. 2011
14EGR1, EGR2
EGR1 and EGR2 involvement in vertebrate tendon differentiation.
Lejard V, Blais F, Guerquin MJ, Bonnet A, Bonnin MA, Havis E, Malbouyres M, Bidaud CB, Maro G, Gilardi-Hebenstreit P, Rossert J, Ruggiero F, Duprez D.
J Biol Chem 286(7):5855-67. doi: 10.1074/jbc.M110.153106. Epub 2010 Dec 20. 2011
15EGR1, IPO7
Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine.
Chen J, Liu MY, Parish CR, Chong BH, Khachigian L.
Int J Biochem Cell Biol 43(6):905-12. doi: 10.1016/j.biocel.2011.03.004. Epub 2011 Mar 17. 2011
16CCK, EGR1, LEP
EGR1 Is a target for cooperative interactions between cholecystokinin and leptin, and inhibition by ghrelin, in vagal afferent neurons.
de Lartigue G, Lur G, Dimaline R, Varro A, Raybould H, Dockray GJ.
Endocrinology 151(8):3589-99. Epub 2010 Jun 9.PMID: 20534729 2010
17EGR1, MMP9
EGR-1 activation by EGF inhibits MMP-9 expression and lymphoma growth.
Bouchard F, Bélanger SD, Biron-Pain K, St-Pierre Y.
Blood 116(5):759-66. Epub 2010 May 14.PMID: 20472833 2010
18EGR1
Mature human neutrophils constitutively express the transcription factor EGR-1.
Cullen EM, Brazil JC, O'Connor CM.
Mol Immunol 47(9):1701-9. Epub 2010 Apr 2.PMID: 20363028 2010
19EGR1, MMP9
Transcription factor Egr-1 is essential for maximal matrix metalloproteinase-9 transcription by tumor necrosis factor alpha.
Shin SY, Kim JH, Baker A, Lim Y, Lee YH.
Mol Cancer Res 8(4):507-19. Epub 2010 Mar 23.PMID: 20332214 2010
20EGR1, PTEN
EGR1 reactivation by histone deacetylase inhibitors promotes synovial sarcoma cell death through the PTEN tumor suppressor.
Su L, Cheng H, Sampaio AV, Nielsen TO, Underhill TM.
Oncogene 29(30):4352-61. Epub 2010 May 31.PMID: 20514024 2010
21EGR1
Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b.
Hu CT, Chang TY, Cheng CC, Liu CS, Wu JR, Li MC, Wu WS.
FEBS J. 277(5):1202-18. 2010
22EGR1
T-box 2 represses NDRG1 through an EGR1-dependent mechanism to drive the proliferation of breast cancer cells.
Redmond KL, Crawford NT, Farmer H, D'Costa ZC, O'Brien GJ, Buckley NE, Kennedy RD, Johnston PG, Harkin DP, Mullan PB.
Oncogene. 29(22):3252-62 2010
23EGR1, PGF
Placenta growth factor-induced early growth response 1 (Egr-1) regulates hypoxia-inducible factor-1alpha (HIF-1alpha) in endothelial cells.
Patel N, Kalra VK.
J Biol Chem 285(27):20570-9. Epub 2010 May 6. 2010
24EGR1, EGR2, EGR3
EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin.
Kumbrink J, Kirsch KH, Johnson JP.
J Cell Biochem 111(1):207-17. doi: 10.1002/jcb.22690. 2010
25EGR1, SOX18
Early growth response protein 1 acts as an activator of SOX18 promoter.
Petrovic I, Kovacevic-Grujicic N, Stevanovic M.
Exp Mol Med 42(2):132-42. doi: 10.3858/emm.2010.42.2.015. 2010
26EGR1, EGR2
The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation.
Boyle KB, Hadaschik D, Virtue S, Cawthorn WP, Ridley SH, O'Rahilly S, Siddle K.
Cell Death Differ 16(5):782-9. Epub 2009 Feb 20. 2009
27EGR1
Early growth response 1 (EGR1): a gene with as many names as biological functions.
DeLigio JT, Zorio DA.
Cancer Biol Ther 8(20):1889-92. Epub 2009 Oct 14.PMID: 20009530 2009
28ATF5, EGR1
Identification of a novel DNA binding site and a transcriptional target for activating transcription factor 5 in c6 glioma and mcf-7 breast cancer cells.
Li G, Li W, Angelastro JM, Greene LA, Liu DX.
Mol Cancer Res 7(6):933-43. doi: 10.1158/1541-7786.MCR-08-0365. Epub 2009 Jun 16. 2009
29EGR1, EGR2, EGR3
Epidermal-growth-factor-induced proliferation of astrocytes requires Egr transcription factors.
Mayer SI, Rössler OG, Endo T, Charnay P, Thiel G.
J Cell Sci 122(Pt 18):3340-50. doi: 10.1242/jcs.048272. Epub 2009 Aug 25. 2009
30EGR1, UBE2S, VHL
Egr-1 and serum response factor are involved in growth factors- and serum-mediated induction of E2-EPF UCP expression that regulates the VHL-HIF pathway.
Lim JH, Jung CR, Lee CH, Im DS.
J Cell Biochem 105(4):1117-27.PMID: 18780286 2008
31EGR1
The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells.
Min IM, Pietramaggiori G, Kim FS, Passegué E, Stevenson KE, Wagers AJ.
Cell Stem Cell 2(4):380-91.PMID: 18397757 2008
32EGR1, G3BP1
Erythropoietin receptor-mediated Egr-1 activation: structural requirements and functional implications.
Schulze C, Büchse T, Mikkat S, Bittorf T.
Cell Signal 20(10):1848-54. Epub 2008 Jun 27. 2008
33FGF23, EGR1, NAB2
FGF23 induces expression of two isoforms of NAB2, which are corepressors of Egr-1.
Fukuda T, Kanomata K, Nojima J, Urakawa I, Suzawa T, Imada M, Kukita A, Kamijo R, Yamashita T, Katagiri T.
Biochem Biophys Res Commun 353(1):147-51. Epub 2006 Dec 11. 2007
34EGR1, EGR3
Egr3, a synaptic activity regulated transcription factor that is essential for learning and memory.
Li L, Yun SH, Keblesh J, Trommer BL, Xiong H, Radulovic J, Tourtellotte WG.
Mol Cell Neurosci 35(1):76-88. Epub 2007 Feb 12. 2007
35EGR1
Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders.
Joslin JM, Fernald AA, Tennant TR, Davis EM, Kogan SC, Anastasi J, Crispino JD, Le Beau MM.
Blood 110(2):719-26. Epub 2007 Apr 9. 2007
36EGR1
Relative axial myopia in Egr-1 (ZENK) knockout mice.
Schippert R, Burkhardt E, Feldkaemper M, Schaeffel F.
Invest Ophthalmol Vis Sci. 48(1):11-7. 2007
37TOPBP1, EGR1
The transcription factor Egr-1 is a regulator of the human TopBP1 gene.
Usskilat C, Skerka C, Saluz HP, Hanel F.
Gene 380(2):144-50. Epub 2006 Jun 8. 2006
38EGR1, GNAQ
Early growth response transcription factor EGR-1 regulates Galphaq gene in megakaryocytic cells.
Jalagadugula G, Dhanasekaran DN, Kim S, Kunapuli SP, Rao AK.
J Thromb Haemost 4(12):2678-86. Epub 2006 Sep 22. 2006
39COL1A2, EGR1
The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression.
Chen SJ, Ning H, Ishida W, Sodin-Semrl S, Takagawa S, Mori Y, Varga J.
J Biol Chem 281(30):21183-97. Epub 2006 May 15. 2006
40NAB1, EGR1
The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy.
Buitrago M, Lorenz K, Maass AH, Oberdorf-Maass S, Keller U, Schmitteckert EM, Ivashchenko Y, Lohse MJ, Engelhardt S.
Nat Med 11(8):837-844. Epub 2005 Jul 17. 2005
41FN1, POU5F1, MMP7, EGR1, AFP, IRX1, NR6A1
Gene expression profiling differentiates germ cell tumors from other cancers and defines subtype-specific signatures.
Juric D, Sale S, Hromas RA, Yu R, Wang Y, Duran GE, Tibshirani R, Einhorn LH, Sikic BI.
Proc Natl Acad Sci U S A 102(49):17763-8. Epub 2005 Nov 23. 2005
42ATF3, EGR1
Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene.
Bottone FG Jr, Moon Y, Alston-Mills B, Eling TE.
J Pharmacol Exp Ther 315(2):668-77. Epub 2005 Aug 3. 2005
43EGR1
Delayed hepatocellular mitotic progression and impaired liver regeneration in early growth response-1-deficient mice.
Liao Y, Shikapwashya ON, Shteyer E, Dieckgraefe BK, Hruz PW, Rudnick DA.
J Biol Chem. 279(41):43107-16. 2004
44TNFSF10, CCL25, IFI30, EGR1
Egr-1 target genes in human endothelial cells identified by microarray analysis.
Fu M, Zhu X, Zhang J, Liang J, Lin Y, Zhao L, Ehrengruber MU, Chen YE.
Gene 315:33-41. 2003
45EGR1, F3, CD40LG
Induction of tissue factor expression in human endothelial cells by CD40 ligand is mediated via activator protein 1, nuclear factor kappa B, and Egr-1.
Bavendiek U, Libby P, Kilbride M, Reynolds R, Mackman N, Schonbeck U.
J Biol Chem 277(28):25032-9. 2002
46EGR1
Thymocyte development in early growth response gene 1-deficient mice.
Bettini M, Xi H, Milbrandt J, Kersh GJ.
J Immunol 169(4):1713-20. 2002
47EGR1, MAOB
Activation of human monoamine oxidase B gene expression by a protein kinase C MAPK signal transduction pathway involves c-Jun and Egr-1.
Wong WK, Ou XM, Chen K, Shih JC.
J Biol Chem 277(25):22222-30. 2002
48EGR1, DIDAN
Early growth response factor-1 is a critical transcriptional mediator of peroxisome proliferator-activated receptor-gamma 1 gene expression in human aortic smooth muscle cells.
Fu M, Zhang J, Lin Y, Zhu X, Ehrengruber MU, Chen YE.
J Biol Chem 277(30):26808-14. 2002
49EGR1
EGR1 target genes in prostate carcinoma cells identified by microarray analysis.
Svaren J, Ehrig T, Abdulkadir SA, Ehrengruber MU, Watson MA, Milbrandt J.
J Biol Chem 275(49):38524-31. 2000
50ADRA2A, ADRB1, AGTR1, CAFG, CD36, CETP, CSF1, CSF2, CYP11B2, ECE1, EDN1, EDNRA, EDNRB, EGR1, F2R, FGA, FGB, FHBL1, HGF, ICAM1, IGF1, IL1A, IL6, LPA, MGP, MSR1, MTTP, NOS2, NOS3, PDGFA, PDGFRA, SELP, TGFB1, TNF, VCAM1, VDR
Sequence diversity in 36 candidate genes for cardiovascular disorders.
Cambien F, Poirier O, Nicaud V, Herrmann SM, Mallet C, Ricard S, Behague I, Hallet V, Blanc H, Loukaci V, Thillet J, Evans A, Ruidavets JB, Arveiler D, Luc G, Tiret L.
Am J Hum Genet 65(1):183-91. 1999
51SH3TC2, EGR1
Genetic, cytogenetic and physical refinement of the autosomal recessive CMT linked to 5q31-q33: exclusion of candidate genes including EGR1.
No authors listed] Related Articles
Eur J Hum Genet 7(8):849-59 1999
52CREBBP, EGR1
cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1).
Silverman ES, et al.
Biochem J 336 : 183-189. 1998
53EGR1
Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1).
Lee SL, Sadovsky Y, Swirnoff AH, Polish JA, Goda P, Gavrilina G, Milbrandt J.
Science. 273(5279):1219-21. 1996
54EGR1, IL9, CSF2, TSG5D
Physical mapping of the minimal region of loss in 5q- chromosome. (chromosome 5/deletion/leukemia).
Fairman J, et al.
Proc Natl Acad Sci U S A 92 : 7406-7410. 1995
55EGR1
Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals.
Cao X, et al.
Mol Cell Biol 10 : 1931-1939. 1990
56EGR1
Structure, chromosome mapping and regulation of the mouse zinc finger gene Krox-24, evidence for a common regulatory pathway for immediate-early serum response genes.
Janssen-Timmen U, Lemaire P, Mattei MG, Revelant O, Charnay P.
Gene 80 : 325-336. 1989
57EGR1
A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization.
Sukhatme VP, et al.
Cell 53 : 37-43. 1988