Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DYNLT1 contributors: mct/npt/shn/pgu - updated : 10-05-2017
HGNC name dynein, light chain, Tctex-type 1
HGNC id 11697
Location 6q25.3      Physical location : 159.057.508 - 159.065.804
Synonym name
  • t-complex-associated-testis-expressed 1-like 1
  • protein CW-1
    • Synonym symbol(s) TCTEL1, CW-1, tctex-1, MGC111571, TCTEX1
    DNA
    TYPE functioning gene
    STRUCTURE 8.24 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D6S363 - D6S437 - DYNLT1 - D6S1614 - D6S1035 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 713 14 113 expressed in adult neural stem cells 2006 16628620
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineparathyroid   highly
    Reproductivemale systemtestis   
    Respiratorylung    
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two heavy chains havin ATPase and motor activities
  • a group of accessory polypeptides
  • a dynein light chain involved in cargo binding
    • HOMOLOGY
    interspecies ortholog to Dynlt1, Rattus norvegicus
    ortholog to DYNLT1, Pan troglodytes
    ortholog to Dynlt1b, Mus musculus
    ortholog to dynlt1, danio rerio
    Homologene
    FAMILY
  • dynein light chain Tctex-type family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • DYNLT1 and RAB3D intimately associate with the dynein motor complex and microtubules in osteoclasts
  • localized around the ER of human fibroblasts
    • basic FUNCTION
  • major motor protein complex responsible for minus-end microtubule-based motile processes
  • dynein light chain involved in cargo binding and has a key role in multiple steps of hippocampal neuron development, including initial neurite sprouting, axon specification, and later dendritic elaboration
  • play a role in G protein signaling activation and neuronal growth
  • a negative regulator of ARHGEF2
  • required to determine the orientation of mitotic precursor cell divisions in vivo and its interaction with Arhgef2 is necessary to regulate cortical neurogenesis
  • important in embryonic neural precursors, a part of an essential pathway that regulates the genesis of neurons from cortical precursor cells, potentially by regulating mitotic spindle orientation
  • role of DYNLT1 in S-phase entry is dispensable in non-ciliated cells
  • DYNLT1 phosphorylated at Thr 94 is selectively enriched at the ciliary transition zones of cortical neural progenitors, and has a key role in controlling G(1) length, cell cycle entry and fate determination of these cells during corticogenesis
  • has critical functions as an adapter between the dynein motor complexes and cytoplasmic vesicles, suggesting the involvement of the DKK3 protein in the ER-related vesicular trafficking system
    • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS development , nervous system
    text inhibits neurogenesis
    PATHWAY
    metabolism
    signaling
    a component
  • at least two heavy chains and a number of intermediate and light chains
  • DYNLT1-DYNLT3 heterodimer did not bind to the intermediate chain (intermediate chain binding limits the incorporation of DYNLT heterodimers into the dynein complex and demonstrates that only a subset of the possible combinations of subunit isoforms can be utilized during the assembly of the dynein cargo binding domain)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Fyn kinase (FYN)
  • double C2-like domains alpha and beta (DOC22A,DOC2B)
  • rhodopsin (RHO)
  • Trk neurotrophin receptor 1 (NTRK1)
  • Voltage-dependent anion-selective channel 1 (VDAC1)
  • poliovirus receptor CD155
  • bone morphogenetic receptor type II (BMPR-II)
  • parathyroid hormone receptor (PTHR)
  • Herpes simplex virus type 1 capsid protein VP26
  • heat shock protein, alpha-crystallin-related, B9 (HSPB9)
  • G protein beta gamma subunit
  • Rho/Rac guanine nucleotide exchange factor (GEF) 2 (ARHGEF2)
  • is a RAB3D-interacting partner (binds specifically to RAB3D in a GTP-dependent manner and co-occupies RAB3D-bearing vesicles in bone-resorbing osteoclasts)
  • is a novel interaction partner of DKK3 (interaction and functions occur around the ER)
    • cell & other
    REGULATION
    Other
  • phosphorylated by bone morphogenetic receptor type II (BMPR-II)
    • ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • genetic knockdown of mouse Dynlt1 in radial precursors promotes neurogenesis and depletes cycling cortical precursors