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FLASH GENE
Symbol DYNLT1 contributors: mct/npt/shn/pgu - updated : 10-05-2017
HGNC name dynein, light chain, Tctex-type 1
HGNC id 11697
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two heavy chains havin ATPase and motor activities
  • a group of accessory polypeptides
  • a dynein light chain involved in cargo binding
  • HOMOLOGY
    interspecies ortholog to Dynlt1, Rattus norvegicus
    ortholog to DYNLT1, Pan troglodytes
    ortholog to Dynlt1b, Mus musculus
    ortholog to dynlt1, danio rerio
    Homologene
    FAMILY
  • dynein light chain Tctex-type family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • DYNLT1 and RAB3D intimately associate with the dynein motor complex and microtubules in osteoclasts
  • localized around the ER of human fibroblasts
  • basic FUNCTION
  • major motor protein complex responsible for minus-end microtubule-based motile processes
  • dynein light chain involved in cargo binding and has a key role in multiple steps of hippocampal neuron development, including initial neurite sprouting, axon specification, and later dendritic elaboration
  • play a role in G protein signaling activation and neuronal growth
  • a negative regulator of ARHGEF2
  • required to determine the orientation of mitotic precursor cell divisions in vivo and its interaction with Arhgef2 is necessary to regulate cortical neurogenesis
  • important in embryonic neural precursors, a part of an essential pathway that regulates the genesis of neurons from cortical precursor cells, potentially by regulating mitotic spindle orientation
  • role of DYNLT1 in S-phase entry is dispensable in non-ciliated cells
  • DYNLT1 phosphorylated at Thr 94 is selectively enriched at the ciliary transition zones of cortical neural progenitors, and has a key role in controlling G(1) length, cell cycle entry and fate determination of these cells during corticogenesis
  • has critical functions as an adapter between the dynein motor complexes and cytoplasmic vesicles, suggesting the involvement of the DKK3 protein in the ER-related vesicular trafficking system
  • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS development , nervous system
    text inhibits neurogenesis
    PATHWAY
    metabolism
    signaling
    a component
  • at least two heavy chains and a number of intermediate and light chains
  • DYNLT1-DYNLT3 heterodimer did not bind to the intermediate chain (intermediate chain binding limits the incorporation of DYNLT heterodimers into the dynein complex and demonstrates that only a subset of the possible combinations of subunit isoforms can be utilized during the assembly of the dynein cargo binding domain)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Fyn kinase (FYN)
  • double C2-like domains alpha and beta (DOC22A,DOC2B)
  • rhodopsin (RHO)
  • Trk neurotrophin receptor 1 (NTRK1)
  • Voltage-dependent anion-selective channel 1 (VDAC1)
  • poliovirus receptor CD155
  • bone morphogenetic receptor type II (BMPR-II)
  • parathyroid hormone receptor (PTHR)
  • Herpes simplex virus type 1 capsid protein VP26
  • heat shock protein, alpha-crystallin-related, B9 (HSPB9)
  • G protein beta gamma subunit
  • Rho/Rac guanine nucleotide exchange factor (GEF) 2 (ARHGEF2)
  • is a RAB3D-interacting partner (binds specifically to RAB3D in a GTP-dependent manner and co-occupies RAB3D-bearing vesicles in bone-resorbing osteoclasts)
  • is a novel interaction partner of DKK3 (interaction and functions occur around the ER)
  • cell & other
    REGULATION
    Other
  • phosphorylated by bone morphogenetic receptor type II (BMPR-II)
  • ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • genetic knockdown of mouse Dynlt1 in radial precursors promotes neurogenesis and depletes cycling cortical precursors