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FLASH GENE
Symbol DUSP22 contributors: - updated : 18-03-2006
HGNC name dual specificity phosphatase 22
HGNC id 16077
Location 6p24.3      Physical location : 292.100 - 351.353
Synonym name
  • JNK-stimulating phosphatase 1
  • mitogen-activated protein kinase phosphatase X
  • homolog of mouse dual specificity phosphatase LMW-DSP2
  • VHR-related MKPX (VHX)
  • Synonym symbol(s) JSP1, LMW-DSP2, MKPX
    DNA
    TYPE functioning gene
    STRUCTURE 59.00 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC389451 6 LOC389451 HLA-DRB9 6p21.3 major histocompatibility complex, class II, DR beta 9 (pseudogene) LOC391863 6 similar to Olfactory receptor 4F3 HLA-DRB5 6p21.3 major histocompatibility complex, class II, DR beta 5 LOC389356 6 similar to bA476I15.3 (novel protein similar to septin) HLA-DRB6 6p21.3 major histocompatibility complex, class II, DR beta 6 (pseudogene) HLA-DRB1 6p21.3 major histocompatibility complex, class II, DR beta 1 C6orf35 6q25.3 chromosome 6 open reading frame 35 LOC389357 6 LOC389357 DUSP22 6p24.3 dual specificity phosphatase 22 IRF4 6p25-p23 interferon regulatory factor 4 SEC5 LOC391990 6 similar to serine palmitoyltransferase, long chain base subunit 2; serine palmitoyltransferase, subunit II HUS1B 6p25.3 HUS1 checkpoint homolog b (S. pombe) LOC340177 6q27 hypothetical LOC340177 LOC389452 6 LOC389452 LOC391991 6 similar to lysR-like transcriptional regulator LOC391992 6 similar to putative heavy metal transporter LOC391993 6 similar to F22G5.20 LOC391994 6 similar to Hypothetical protein FLJ30525 LOC221768 6p25.3 similar to ENSANGP00000010305 FOXQ1 6p25-p23 forkhead box Q1 LOC389358 6 LOC389358 FOXF2 6p25.3 forkhead box F2 LOC221766 6p25.3 hypothetical LOC221766 LOC389359 6 LOC389359 LOC389360 6 LOC389360 LOC389361 6 LOC389361 FOXC1 6p25 forkhead box C1 GMDS 6p25 GDP-mannose 4,6-dehydratase
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Endocrinepancreas    
    Reproductivemale systemtestis   
    Respiratorylung    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connective    
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    one single DSP catalytic domain
    HOMOLOGY
    interspecies homolog to murine Lmw-dsp2
    intraspecies homolog to DUSP15
    Homologene
    FAMILY mitogen-activated protein kinase phosphatase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION may be dephosphorylating and inactivating MAP kinases
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding to P38 and SAPK (dephosphorylation and deactivaction)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS