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FLASH GENE

Symbol

DUSP22

contributors: - updated : 18-03-2006

HGNC name	dual specificity phosphatase 22
HGNC id	16077

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	59.00 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Cardiovascular heart         Endocrine pancreas         Reproductive male system testis       Respiratory lung         Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective         Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one single DSP catalytic domain

HOMOLOGY

interspecies

homolog to murine Lmw-dsp2

intraspecies

homolog to DUSP15

Homologene

FAMILY

mitogen-activated protein kinase phosphatase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION

may be dephosphorylating and inactivating MAP kinases

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binding to P38 and SAPK (dephosphorylation and deactivaction)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS