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FLASH GENE
Symbol DTD1 contributors: mct - updated : 25-08-2016
HGNC name D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae)
HGNC id 16219
Location 20p11.23      Physical location : 18.568.555 - 18.744.558
Synonym name
  • histidyl-tRNA synthetase 2
  • chromosome 20 open reading frame 88
  • histidyl-tRNA synthetase-related
  • tyrdeacylase 1
    • Synonym symbol(s) C20orf88, HARS2, DUEB, MGC119131, MGC41905, bA379J5.3, bA555E18.1, pqn-68
    EC.number 6.1.1.21
    DNA
    TYPE functioning gene
    STRUCTURE 176.02 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1387 23 209 - 2007 17264083
    5 - 2466 - 213 - 2007 17264083
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    Nervousbrain    
    Reproductivefemale systemovary   
     female systemuterus   
     male systemtestis   
    Respiratoryrespiratory tractlarynx   
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal 150-AA domain shows strong evolutionary conservation with bacterial and eukaryotic aminoacyl-tRNA proofreading enzymes, and core is shown to display both D-aminoacyl-tRNA deacylase activity and ATPase activity
  • C-terminal portion of the enzyme is disordered and not essential for dimerization, but this region is essential for DNA binding in vitro and becomes ordered in the presence of DNA
    • HOMOLOGY
    interspecies homolog to murine Hars2
    Homologene
    FAMILY
  • DTD family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • hydrolyzing D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr)
  • essential replication factor that is regulated by CDC7 and PPP2CA
  • rapidly cycles between dephosphorylated and rephosphorylated forms during S phase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ORC2, MCM3, and DTD1 were bound at an ectopic MYC replicator, where deletion of sequences essential for origin activity was associated with the loss of DTD1 binding or the alteration of chromatin structure and loss of MCM3 binding
  • coordinated binding of DTD1 and CDC45 to origins and the physical interactions of DTD1, CDC45, and TOPBP1 suggest that complexes of these proteins are necessary for replication initiation
  • binds to replication origins coordinately with the minichromosome maintenance (MCM) helicase and the helicase activator CDC45
  • CDC7 phosphorylation of DTD1 is important for efficient replication initiation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS