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FLASH GENE

Symbol

DTD1

contributors: mct - updated : 25-08-2016

HGNC name	D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae)
HGNC id	16219

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	176.02 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_080820 6 - 1387 NP_543010 23 209 - 2007 17264083 NM_001318043 5 - 2466 NP_001304972 - 213 - 2007 17264083

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen         Nervous brain         Reproductive female system ovary         female system uterus         male system testis       Respiratory respiratory tract larynx       Visual eye

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal 150-AA domain shows strong evolutionary conservation with bacterial and eukaryotic aminoacyl-tRNA proofreading enzymes, and core is shown to display both D-aminoacyl-tRNA deacylase activity and ATPase activity
	C-terminal portion of the enzyme is disordered and not essential for dimerization, but this region is essential for DNA binding in vitro and becomes ordered in the presence of DNA

HOMOLOGY

interspecies

homolog to murine Hars2

Homologene

FAMILY

DTD family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	hydrolyzing D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr)
	essential replication factor that is regulated by CDC7 and PPP2CA
	rapidly cycles between dephosphorylated and rephosphorylated forms during S phase

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

aminoacid

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	ORC2, MCM3, and DTD1 were bound at an ectopic MYC replicator, where deletion of sequences essential for origin activity was associated with the loss of DTD1 binding or the alteration of chromatin structure and loss of MCM3 binding
	coordinated binding of DTD1 and CDC45 to origins and the physical interactions of DTD1, CDC45, and TOPBP1 suggest that complexes of these proteins are necessary for replication initiation
	binds to replication origins coordinately with the minichromosome maintenance (MCM) helicase and the helicase activator CDC45
	CDC7 phosphorylation of DTD1 is important for efficient replication initiation

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS