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FLASH GENE
Symbol DTD1 contributors: mct - updated : 25-08-2016
HGNC name D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae)
HGNC id 16219
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal 150-AA domain shows strong evolutionary conservation with bacterial and eukaryotic aminoacyl-tRNA proofreading enzymes, and core is shown to display both D-aminoacyl-tRNA deacylase activity and ATPase activity
  • C-terminal portion of the enzyme is disordered and not essential for dimerization, but this region is essential for DNA binding in vitro and becomes ordered in the presence of DNA
    • HOMOLOGY
    interspecies homolog to murine Hars2
    Homologene
    FAMILY
  • DTD family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • hydrolyzing D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr)
  • essential replication factor that is regulated by CDC7 and PPP2CA
  • rapidly cycles between dephosphorylated and rephosphorylated forms during S phase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ORC2, MCM3, and DTD1 were bound at an ectopic MYC replicator, where deletion of sequences essential for origin activity was associated with the loss of DTD1 binding or the alteration of chromatin structure and loss of MCM3 binding
  • coordinated binding of DTD1 and CDC45 to origins and the physical interactions of DTD1, CDC45, and TOPBP1 suggest that complexes of these proteins are necessary for replication initiation
  • binds to replication origins coordinately with the minichromosome maintenance (MCM) helicase and the helicase activator CDC45
  • CDC7 phosphorylation of DTD1 is important for efficient replication initiation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS