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FLASH GENE
Symbol DNAJB13 contributors: mct - updated : 20-09-2016
HGNC name DnaJ (Hsp40) related, subfamily B, member 13
HGNC id 30718
Corresponding disease
ICS36 immotile cilia syndrome 36
Location 11q13.4      Physical location : 73.661.363 - 73.681.331
Synonym name
  • testis spermatogenesis apoptosis-related gene 6 protein
  • testis and spermatogenesis cell-related protein 6
  • Synonym symbol(s) TSARG6, FLJ46748, TSARG5, CILD34, RSPH16A
    DNA
    TYPE functioning gene
    STRUCTURE 19.97 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1875 - 316 - 2004 14970903
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiens
    Reproductivefemale systemoviduct    Homo sapiens
     male systemtestis    Homo sapiens
    Respiratoryrespiratory tracttrachea    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivesperm cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • conserved structure with type II DNAJ (HSP40) family members; the conserved region comprises the DNAJ domain, required for association with HSP70
  • C-terminal domain named DNAJ_C particularly conserved in three other members of the type II DNAJ (HSP40) family, which is involved in substrate binding and presentation
  • HOMOLOGY
    Homologene
    FAMILY type II DNAJ (HSP40) protein family
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • specifically localizes to the axoneme of cilia and flagella
  • basic FUNCTION
  • participates in spermiogenesis and the motility of mature spermatozoa 8)
  • might likely have functions that are specific to sperm flagella, in addition to its functions in the RS multiprotein complexes
  • key role played by DNAJB13 in the proper formation and function of ciliary and flagellar axonemes
  • key role in preserving the integrity of the Central complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ICS36
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS