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FLASH GENE
Symbol DNAJB13 contributors: mct - updated : 20-09-2016
HGNC name DnaJ (Hsp40) related, subfamily B, member 13
HGNC id 30718
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1875 - 316 - 2004 14970903
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Homo sapiens
Reproductivefemale systemoviduct    Homo sapiens
 male systemtestis    Homo sapiens
Respiratoryrespiratory tracttrachea    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivesperm cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved structure with type II DNAJ (HSP40) family members; the conserved region comprises the DNAJ domain, required for association with HSP70
  • C-terminal domain named DNAJ_C particularly conserved in three other members of the type II DNAJ (HSP40) family, which is involved in substrate binding and presentation
  • HOMOLOGY
    Homologene
    FAMILY type II DNAJ (HSP40) protein family
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • specifically localizes to the axoneme of cilia and flagella
  • basic FUNCTION
  • participates in spermiogenesis and the motility of mature spermatozoa 8)
  • might likely have functions that are specific to sperm flagella, in addition to its functions in the RS multiprotein complexes
  • key role played by DNAJB13 in the proper formation and function of ciliary and flagellar axonemes
  • key role in preserving the integrity of the Central complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ICS36
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS