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FLASH GENE
Symbol DNAJB13 contributors: mct - updated : 20-09-2016
HGNC name DnaJ (Hsp40) related, subfamily B, member 13
HGNC id 30718
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved structure with type II DNAJ (HSP40) family members; the conserved region comprises the DNAJ domain, required for association with HSP70
  • C-terminal domain named DNAJ_C particularly conserved in three other members of the type II DNAJ (HSP40) family, which is involved in substrate binding and presentation
  • HOMOLOGY
    Homologene
    FAMILY type II DNAJ (HSP40) protein family
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • specifically localizes to the axoneme of cilia and flagella
  • basic FUNCTION
  • participates in spermiogenesis and the motility of mature spermatozoa 8)
  • might likely have functions that are specific to sperm flagella, in addition to its functions in the RS multiprotein complexes
  • key role played by DNAJB13 in the proper formation and function of ciliary and flagellar axonemes
  • key role in preserving the integrity of the Central complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ICS36
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS