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FLASH GENE
Symbol DNAI1 contributors: mct - updated : 09-05-2007
HGNC name dynein, axonemal, intermediate chain 1
HGNC id 2954
Corresponding disease
ICS2 immotile cilia syndrome 2
Location 9p13.3      Physical location : 34.458.810 - 34.520.981
Synonym name
  • dynein, axonemal, intermediate polypeptide 1
  • dynein intermediate chain DNAI1
    • Synonym symbol(s) MGC26204
    DNA
    TYPE functioning gene
    STRUCTURE 62.00 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  predominantly
    Respiratoryrespiratory tracttrachea   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell
    Respiratoryepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		five WD repeats
    HOMOLOGY
    interspecies ortholog to murine Dnaic1
    ortholog to chimpanzee dnai1
    Homologene
    FAMILY dynein intermediate chain family
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • cilia in respiratory tract
  • flagella of spermatozoa
    • basic FUNCTION
  • dynein intermediate chain, outer arm, may be participating in regulating dynein activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein tubulin
    cell & other microtubules
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ICS2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS